| Online-Ressource |
Verfasst von: | Kurz, Patrick [VerfasserIn]  |
| Stampfl, Ulrike [VerfasserIn]  |
| Christoph, Patricia [VerfasserIn]  |
| Henn, C. [VerfasserIn]  |
| Satzl, Stefanie [VerfasserIn]  |
| Radeleff, Boris [VerfasserIn]  |
| Berger, Irina [VerfasserIn]  |
| Richter, Götz Martin [VerfasserIn]  |
Titel: | Self-expanding nitinol renal artery stents |
Titelzusatz: | comparison of safety and efficacy of bare versus polyzene-F nanocoated stents in a porcine model |
Verf.angabe: | P. Kurz, U. Stampfl, P. Christoph, C. Henn, S. Satzl, B. Radeleff, I. Berger, G.M. Richter |
Jahr: | 2011 |
Umfang: | 10 S. |
Fussnoten: | Published online: 26 October 2010 ; Gesehen am 11.07.2022 |
Titel Quelle: | Enthalten in: CardioVascular and interventional radiology |
Ort Quelle: | Berlin : Springer, 1978 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 34(2011), Seite 139-148 |
ISSN Quelle: | 1432-086X |
Abstract: | To investigate the safety and efficacy of a Polyzene-F nanocoat on new low-profile self-expandable nitinol stents in minipig renal arteries. |
| Objective: To investigate the safety and efficacy of a Polyzene-F nanocoat on new low-profile self-expandable nitinol stents in minipig renal arteries. Materials and Methods: Ten bare nitinol stents (BNS) and 10 stents coated with a 50 nm-thin Polyzene-F coating were randomly implanted into renal arteries of 10 minipigs (4- and 12-week follow-up, 5 animals/group). Thrombogenicity, on-stent surface endothelialization, vessel wall injury, late in-stent stenosis, and peristrut vessel wall inflammation were determined by quantitative angiography and postmortem histomorphometry. Results: In 6 of 10 BNS, >50% stenosis was found, but no stenosis was found in stents with a nanothin Polyzene-F coating. Histomorphometry showed a statistically significant (p < 0.05) different average maximum luminal loss of 55.16% ± 8.43% at 12 weeks in BNS versus 39.77% ± 7.41% in stents with a nanothin Polyzene-F coating. Stents with a nanothin Polyzene-F coating had a significantly (p < 0.05) lower inflammation score after 12 weeks, 1.31 ± 1.17 versus 2.17 ± 0.85 in BNS. The results for vessel wall injury (0.6 ± 0.58 for Polyzene-F-coated stents; 0.72 ± 0.98 for BNS) and re-endothelialization, (1.16 ± 0.43 and 1.23 ± 0.54, respectively) were not statistically significant at 12-week follow-up. No thrombus deposition was observed on the stents at either follow-up time point. Conclusion: Nitinol stents with a nanothin Polyzene-F coating successfully decreased in-stent stenosis and vessel wall inflammation compared with BNS. Endothelialization and vessel wall injury were found to be equal. These studies warrant long-term pig studies (≥120 days) because 12 weeks may not be sufficient time for complete healing; thereafter, human studies may be warranted. |
DOI: | doi:10.1007/s00270-010-9987-7 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00270-010-9987-7 |
| DOI: https://doi.org/10.1007/s00270-010-9987-7 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | In-stent stenosis |
| Interventional radiology |
| Intimal hyperplasia |
| Nitinol |
| Polyzene-F |
| Renal artery stents |
K10plus-PPN: | 1809718511 |
Verknüpfungen: | → Zeitschrift |
Self-expanding nitinol renal artery stents / Kurz, Patrick [VerfasserIn]; 2011 (Online-Ressource)