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Verfasst von:Kurz, Patrick [VerfasserIn]   i
 Stampfl, Ulrike [VerfasserIn]   i
 Christoph, Patricia [VerfasserIn]   i
 Henn, C. [VerfasserIn]   i
 Satzl, Stefanie [VerfasserIn]   i
 Radeleff, Boris [VerfasserIn]   i
 Berger, Irina [VerfasserIn]   i
 Richter, Götz Martin [VerfasserIn]   i
Titel:Self-expanding nitinol renal artery stents
Titelzusatz:comparison of safety and efficacy of bare versus polyzene-F nanocoated stents in a porcine model
Verf.angabe:P. Kurz, U. Stampfl, P. Christoph, C. Henn, S. Satzl, B. Radeleff, I. Berger, G.M. Richter
Jahr:2011
Umfang:10 S.
Fussnoten:Published online: 26 October 2010 ; Gesehen am 11.07.2022
Titel Quelle:Enthalten in: CardioVascular and interventional radiology
Ort Quelle:Berlin : Springer, 1978
Jahr Quelle:2011
Band/Heft Quelle:34(2011), Seite 139-148
ISSN Quelle:1432-086X
Abstract:To investigate the safety and efficacy of a Polyzene-F nanocoat on new low-profile self-expandable nitinol stents in minipig renal arteries.
 Objective: To investigate the safety and efficacy of a Polyzene-F nanocoat on new low-profile self-expandable nitinol stents in minipig renal arteries. Materials and Methods: Ten bare nitinol stents (BNS) and 10 stents coated with a 50 nm-thin Polyzene-F coating were randomly implanted into renal arteries of 10 minipigs (4- and 12-week follow-up, 5 animals/group). Thrombogenicity, on-stent surface endothelialization, vessel wall injury, late in-stent stenosis, and peristrut vessel wall inflammation were determined by quantitative angiography and postmortem histomorphometry. Results: In 6 of 10 BNS, >50% stenosis was found, but no stenosis was found in stents with a nanothin Polyzene-F coating. Histomorphometry showed a statistically significant (p < 0.05) different average maximum luminal loss of 55.16% ± 8.43% at 12 weeks in BNS versus 39.77% ± 7.41% in stents with a nanothin Polyzene-F coating. Stents with a nanothin Polyzene-F coating had a significantly (p < 0.05) lower inflammation score after 12 weeks, 1.31 ± 1.17 versus 2.17 ± 0.85 in BNS. The results for vessel wall injury (0.6 ± 0.58 for Polyzene-F-coated stents; 0.72 ± 0.98 for BNS) and re-endothelialization, (1.16 ± 0.43 and 1.23 ± 0.54, respectively) were not statistically significant at 12-week follow-up. No thrombus deposition was observed on the stents at either follow-up time point. Conclusion: Nitinol stents with a nanothin Polyzene-F coating successfully decreased in-stent stenosis and vessel wall inflammation compared with BNS. Endothelialization and vessel wall injury were found to be equal. These studies warrant long-term pig studies (≥120 days) because 12 weeks may not be sufficient time for complete healing; thereafter, human studies may be warranted.
DOI:doi:10.1007/s00270-010-9987-7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00270-010-9987-7
 DOI: https://doi.org/10.1007/s00270-010-9987-7
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:In-stent stenosis
 Interventional radiology
 Intimal hyperplasia
 Nitinol
 Polyzene-F
 Renal artery stents
K10plus-PPN:1809718511
Verknüpfungen:→ Zeitschrift

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