| |  Online-Ressource |
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| Verfasst von: | Grimm, Marcus Otto Walter [VerfasserIn]  |
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| | Kuchenbecker, Johanna [VerfasserIn] |
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| | Rothhaar, Tatjana L. [VerfasserIn] |
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| | Grösgen, Sven [VerfasserIn] |
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| | Hundsdörfer, Benjamin [VerfasserIn] |
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| | Burg, Verena K. [VerfasserIn] |
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| | Friess, Petra [VerfasserIn] |
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| | Müller, Ulrike C. [VerfasserIn] |
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| | Grimm, Heike S. [VerfasserIn] |
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| | Riemenschneider, Mathias [VerfasserIn] |
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| | Hartmann, Tobias [VerfasserIn] |
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| Titel: | Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease |
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| Verf.angabe: | Marcus O. W. Grimm, Johanna Kuchenbecker, Tatjana L. Rothhaar, Sven Grösgen, Benjamin Hundsdörfer, Verena K. Burg, Petra Friess, Ulrike Müller, Heike S. Grimm, Mathias Riemenschneider, and Tobias Hartmann |
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| Jahr: | 2011 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 11.07.2022 |
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| Titel Quelle: | Enthalten in: Journal of neurochemistry |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1956 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 116(2011), 5, Seite 916-925 |
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| ISSN Quelle: | 1471-4159 |
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| Abstract: | J. Neurochem. (2011) 116, 916-925. Abstract Lipids play an important role as risk or protective factors in Alzheimer’s disease, which is characterized by amyloid plaques composed of aggregated amyloid-beta. Plasmalogens are major brain lipids and controversially discussed to be altered in Alzheimer’s disease (AD) and whether changes in plasmalogens are cause or consequence of AD pathology. Here, we reveal a new physiological function of the amyloid precursor protein (APP) in plasmalogen metabolism. The APP intracellular domain was found in vivo and in vitro to increase the expression of the alkyl-dihydroxyacetonephosphate-synthase (AGPS), a rate limiting enzyme in plasmalogen synthesis. Alterations in APP dependent changes of AGPS expression result in reduced protein and plasmalogen levels. Under the pathological situation of AD, increased amyloid-beta level lead to increased reactive oxidative species production, reduced AGPS protein and plasmalogen level. Accordingly, phosphatidylethanol plasmalogen was decreased in the frontal cortex of AD compared to age matched controls. Our findings elucidate that plasmalogens are decreased as a consequence of AD and regulated by APP processing under physiological conditions. |
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| DOI: | doi:10.1111/j.1471-4159.2010.07070.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/j.1471-4159.2010.07070.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1471-4159.2010.07070.x |
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| | DOI: https://doi.org/10.1111/j.1471-4159.2010.07070.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alkyl-dihydroxyacetonephosphate-synthase |
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| | Alzheimer’s disease |
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| | amyloid-beta |
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| | APP intracellular domain |
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| | plasmalogens |
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| | reactive oxidative species |
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| K10plus-PPN: | 1809785537 |
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| Verknüpfungen: | → Zeitschrift |
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Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer’s disease / Grimm, Marcus Otto Walter [VerfasserIn]; 2011 (Online-Ressource)
