| |  Online-Ressource |
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| Verfasst von: | Langer, Harald [VerfasserIn]  |
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| | Orlova, Valeria V. [VerfasserIn] |
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| | Xie, Changping [VerfasserIn] |
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| | Kaul, Sunil [VerfasserIn] |
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| | Schneider, Darius A. [VerfasserIn] |
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| | Lonsdorf, Anke Susanne [VerfasserIn] |
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| | Fahrleitner, Manuela [VerfasserIn] |
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| | Choi, Eun Young [VerfasserIn] |
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| | Dutoit, Vanessa [VerfasserIn] |
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| | Pellegrini, Manuela [VerfasserIn] |
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| | Grossklaus, Sylvia [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Baretton, Gustavo [VerfasserIn] |
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| | Santoso, Sentot [VerfasserIn] |
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| | Hwang, Sam T. [VerfasserIn] |
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| | Arnold, Bernd [VerfasserIn] |
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| | Chavakis, Triantafyllos [VerfasserIn] |
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| Titel: | A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis |
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| Verf.angabe: | Harald F. Langer, Valeria V. Orlova, Changping Xie, Sunil Kaul, Darius Schneider, Anke S. Lonsdorf, Manuela Fahrleitner, Eun Young Choi, Vanessa Dutoit, Manuela Pellegrini, Sylvia Grossklaus, Peter P. Nawroth, Gustavo Baretton, Sentot Santoso, Sam T. Hwang, Bernd Arnold, and Triantafyllos Chavakis |
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| E-Jahr: | 2011 |
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| Jahr: | June 14 2011 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 13.07.2022 |
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| Titel Quelle: | Enthalten in: Cancer research |
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| Ort Quelle: | Philadelphia, Pa. : AACR, 1916 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 71(2011), 12, Seite 4096-4105 |
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| ISSN Quelle: | 1538-7445 |
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| Abstract: | Hematogenous dissemination of melanoma is a life-threatening complication of this malignant tumor. Here, we identified junctional adhesion molecule-C (JAM-C) as a novel player in melanoma metastasis to the lung. JAM-C expression was identified in human and murine melanoma cell lines, in human malignant melanoma, as well as in metastatic melanoma including melanoma lung metastasis. JAM-C expressed on both murine B16 melanoma cells as well as on endothelial cells promoted the transendothelial migration of the melanoma cells. We generated mice with inactivation of JAM-C. JAM-C−/− mice as well as endothelial-specific JAM-C-deficient mice displayed significantly decreased B16 melanoma cell metastasis to the lung, whereas treatment of mice with soluble JAM-C prevented melanoma lung metastasis. Together, JAM-C represents a novel therapeutic target for melanoma metastasis. |
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| DOI: | doi:10.1158/0008-5472.CAN-10-2794 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1158/0008-5472.CAN-10-2794 |
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| | DOI: https://doi.org/10.1158/0008-5472.CAN-10-2794 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1810084873 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis / Langer, Harald [VerfasserIn]; June 14 2011 (Online-Ressource)
