| Online-Ressource |
Verfasst von: | Faßbender, Klaus [VerfasserIn]  |
| Schneider, Susanne [VerfasserIn]  |
| Bertsch, Thomas [VerfasserIn]  |
| Schlüter, Dirk [VerfasserIn]  |
| Fatar, Marc [VerfasserIn]  |
| Ragoschke-Schumm, Andreas [VerfasserIn]  |
| Kühl, Sandra [VerfasserIn]  |
| Kischka, Udo [VerfasserIn]  |
| Hennerici, Michael G. [VerfasserIn]  |
Titel: | Temporal profile of release of interleukin-1β in neurotrauma |
Verf.angabe: | Klaus Fassbender, Susanne Schneider, Thomas Bertsch, Dirk Schlueter, Marc Fatar, Andreas Ragoschke, Sandra Kühl, Udo Kischka, Michael Hennerici |
E-Jahr: | 2000 |
Jahr: | 18 April 2000 |
Umfang: | 4 S. |
Fussnoten: | Gesehen am 13.07.2022 |
Titel Quelle: | Enthalten in: Neuroscience letters |
Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
Jahr Quelle: | 2000 |
Band/Heft Quelle: | 284(2000), 3, Seite 135-138 |
ISSN Quelle: | 1872-7972 |
Abstract: | Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotrauma, mRNA expression of IL-1beta was detected whereas immunoreactivity for the IL-1beta protein was negative. Concentrations of extracellularly secreted IL-1beta protein gradually increased, peaked at day 2 and decreased thereafter. Drugs acting on mononuclear phagocytes significantly modulated IL-1beta secretion. This so far unrecognized acuity of IL-1beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response. |
DOI: | doi:10.1016/s0304-3940(00)00977-0 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/s0304-3940(00)00977-0 |
| DOI: https://doi.org/10.1016/s0304-3940(00)00977-0 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Animals |
| Brain |
| Brain Injuries |
| Chloroquine |
| Colchicine |
| Immunohistochemistry |
| Inflammation |
| Interferon-gamma |
| Interleukin-1 |
| Lipopolysaccharides |
| Male |
| Microdialysis |
| Microglia |
| Rats |
| Rats, Wistar |
| RNA, Messenger |
| Serpins |
| Time Factors |
| Viral Proteins |
K10plus-PPN: | 1810089166 |
Verknüpfungen: | → Zeitschrift |
Temporal profile of release of interleukin-1β in neurotrauma / Faßbender, Klaus [VerfasserIn]; 18 April 2000 (Online-Ressource)