| |  Online-Ressource |
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| Verfasst von: | Faßbender, Klaus [VerfasserIn]  |
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| | Schneider, Susanne [VerfasserIn] |
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| | Bertsch, Thomas [VerfasserIn] |
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| | Schlüter, Dirk [VerfasserIn] |
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| | Fatar, Marc [VerfasserIn] |
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| | Ragoschke-Schumm, Andreas [VerfasserIn] |
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| | Kühl, Sandra [VerfasserIn] |
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| | Kischka, Udo [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| Titel: | Temporal profile of release of interleukin-1β in neurotrauma |
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| Verf.angabe: | Klaus Fassbender, Susanne Schneider, Thomas Bertsch, Dirk Schlueter, Marc Fatar, Andreas Ragoschke, Sandra Kühl, Udo Kischka, Michael Hennerici |
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| E-Jahr: | 2000 |
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| Jahr: | 18 April 2000 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 13.07.2022 |
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| Titel Quelle: | Enthalten in: Neuroscience letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2000 |
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| Band/Heft Quelle: | 284(2000), 3, Seite 135-138 |
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| ISSN Quelle: | 1872-7972 |
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| Abstract: | Timing and extent of trauma-induced release of interleukin-1beta (IL-1beta) in extracellular fluid of the CNS were analyzed. In brain tissue perfusates obtained by in vivo microdialysis a marked release of IL-1beta was unexpectedly detected within less than 60 min. At such an early stage of neurotrauma, mRNA expression of IL-1beta was detected whereas immunoreactivity for the IL-1beta protein was negative. Concentrations of extracellularly secreted IL-1beta protein gradually increased, peaked at day 2 and decreased thereafter. Drugs acting on mononuclear phagocytes significantly modulated IL-1beta secretion. This so far unrecognized acuity of IL-1beta release demonstrated here, may represent a precondition for the orchestrating role of this mediator in the cascade of inflammatory host response. |
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| DOI: | doi:10.1016/s0304-3940(00)00977-0 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/s0304-3940(00)00977-0 |
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| | DOI: https://doi.org/10.1016/s0304-3940(00)00977-0 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Brain |
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| | Brain Injuries |
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| | Chloroquine |
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| | Colchicine |
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| | Immunohistochemistry |
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| | Inflammation |
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| | Interferon-gamma |
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| | Interleukin-1 |
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| | Lipopolysaccharides |
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| | Male |
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| | Microdialysis |
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| | Microglia |
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| | Rats |
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| | Rats, Wistar |
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| | RNA, Messenger |
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| | Serpins |
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| | Time Factors |
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| | Viral Proteins |
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| K10plus-PPN: | 1810089166 |
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| Verknüpfungen: | → Zeitschrift |
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Temporal profile of release of interleukin-1β in neurotrauma / Faßbender, Klaus [VerfasserIn]; 18 April 2000 (Online-Ressource)
