Impact of DNA repair kinetics and dose rate on RBE predictions in the UNIVERSE

• Verfasst von: Liew, Hans [VerfasserIn]
• Verfasst von: Mein, Stewart [VerfasserIn]
• Verfasst von: Tessonnier, Thomas [VerfasserIn]
• Verfasst von: Karger, Christian [VerfasserIn]
• Verfasst von: Abdollahi, Amir [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Dokić, Ivana [VerfasserIn]
• Verfasst von: Mairani, Andrea [VerfasserIn]
• Titel: Impact of DNA repair kinetics and dose rate on RBE predictions in the UNIVERSE
• Verf.angabe: Hans Liew, Stewart Mein, Thomas Tessonnier, Christian P. Karger, Amir Abdollahi, Jürgen Debus, Ivana Dokic and Andrea Mairani
• E-Jahr: 2022
• Jahr: 3 June 2022
• Umfang: 18 S.
• Fussnoten: Gesehen am 15.07.2022
• Titel Quelle: Enthalten in: International journal of molecular sciences
• Ort Quelle: Basel : Molecular Diversity Preservation International, 2000
• Jahr Quelle: 2022
• Band/Heft Quelle: 23(2022), 11, Artikel-ID 6268, Seite 1-18
• ISSN Quelle: 1422-0067
• ISSN Quelle: 1661-6596
• DOI: doi:10.3390/ijms23116268
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: DNA repair
• Sach-SW: dose rate
• Sach-SW: ion beam therapy
• Sach-SW: ionizing radiation
• Sach-SW: modeling
• Sach-SW: rat spinal cord
• Sach-SW: RBE
• Sach-SW: UNIVERSE
• K10plus-PPN: 1810604214

Abstract

Accurate knowledge of the relative biological effectiveness (RBE) and its dependencies is crucial to support modern ion beam therapy and its further development. However, the influence of different dose rates of the reference radiation and ion beam are rarely considered. The ion beam RBE-model within our “UNIfied and VERSatile bio response Engine” (UNIVERSE) is extended by including DNA damage repair kinetics to investigate the impact of dose-rate effects on the predicted RBE. It was found that dose-rate effects increase with dose and biological effects saturate at high dose-rates, which is consistent with data- and model-based studies in the literature. In a comparison with RBE measurements from a high dose in-vivo study, the predictions of the presented modification were found to be improved in comparison to the previous version of UNIVERSE and existing clinical approaches that disregard dose-rate effects. Consequently, DNA repair kinetics and the different dose rates applied by the reference and ion beams might need to be considered in biophysical models to accurately predict the RBE. Additionally, this study marks an important step in the further development of UNIVERSE, extending its capabilities in giving theoretical guidance to support progress in ion beam therapy.