Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults

• Verfasst von: Eichkorn, Tanja [VerfasserIn]
• Verfasst von: Bauer, Julia [VerfasserIn]
• Verfasst von: Bahn, Emanuel [VerfasserIn]
• Verfasst von: Lischalk, Jonathan W. [VerfasserIn]
• Verfasst von: Meixner, Eva [VerfasserIn]
• Verfasst von: Sandrini, Elisabetta [VerfasserIn]
• Verfasst von: Regnery, Sebastian [VerfasserIn]
• Verfasst von: Held, Thomas [VerfasserIn]
• Verfasst von: Hörner-Rieber, Juliane [VerfasserIn]
• Verfasst von: Alber, Markus [VerfasserIn]
• Verfasst von: Herfarth, Klaus [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: König, Laila [VerfasserIn]
• Verfasst von: Harrabi, Semi B. [VerfasserIn]
• Titel: Radiation-induced contrast enhancement following proton radiotherapy for low-grade glioma depends on tumor characteristics and is rarer in children than adults
• Verf.angabe: Tanja Eichkorn, Julia Bauer, Emanuel Bahn, Jonathan W. Lischalk, Eva Meixner, Elisabetta Sandrini, Sebastian Regnery, Thomas Held, Juliane Hörner-Rieber, Markus Alber, Klaus Herfarth, Jürgen Debus, Laila König, Semi Harrabi
• E-Jahr: 2022
• Jahr: 20 May 2022
• Umfang: 11 S.
• Fussnoten: Gesehen am 18.07.2022
• Titel Quelle: Enthalten in: Radiotherapy and oncology
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1983
• Jahr Quelle: 2022
• Band/Heft Quelle: 172(2022), Seite 54-64
• ISSN Quelle: 1879-0887
• DOI: doi:10.1016/j.radonc.2022.05.005
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Low-grade glioma (LGG)
• Sach-SW: Pediatric brain tumors
• Sach-SW: Proton radiotherapy
• Sach-SW: Pseudoprogression/Radiation necrosis
• Sach-SW: Radiation-induced contrast enhancements (RICE)
• K10plus-PPN: 1810702623

Abstract

Background and purpose - Proton beam radiotherapy (PRT) is used in the treatment of low-grade glioma (LGG) to mitigate long-term sequelae. Following PRT, increased rates of radiation-induced contrast enhancements (RICE) are suspected but poorly understood. - Materials and methods - We analyzed consecutive 227 patients (42 children and 185 adults) treated with PRT (54 Gy RBE) for LGG from 2010 to 2020 and followed with serial clinical exams and magnetic resonance imaging for in median 5.6 years. - Results - Tumors were graded WHO 1 in a minority (n = 22, 12%) of adults, but a majority of children (n = 29, 69%). In contrast, tumors were graded WHO 2 in the majority (n = 160, 87%) of adults and a minority of children (n = 10, 24%). Five-year overall survival following PRT was 81% in adults and 91% in children. The risk of RICE was 5-fold more frequent in adults (25%) vs. children (5%; p = 0.0043). In children and adults, RICE were symptomatic in 50% and 55% (n = 1 and 26) of cases with CTCAE grade 0 in 47% (n = 23), grade 1 in 25% (n = 12), 0% grade 2 (n = 0) and 29% grade 3 (n = 14), respectively. In adults, RICE risk was associated to WHO grading (8% in WHO grade 1 vs. 24% in WHO grade 2, p = 0.026), independent of age (p = 0.44) and irradiation dose (p = 0.005), but not independent of IDH mutational status. - Conclusions - These data demonstrate effectiveness of PRT for LGG in both children and adults. The RICE risk is lower in children which are a main target group for PRT and differs with WHO grading.