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| Verfasst von: | Ballabio, Claudio [VerfasserIn]  |
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| | Gianesello, Matteo [VerfasserIn] |
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| | Lago, Chiara [VerfasserIn] |
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| | Okonechnikov, Konstantin [VerfasserIn] |
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| | Anderle, Marica [VerfasserIn] |
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| | Aiello, Giuseppe [VerfasserIn] |
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| | Antonica, Francesco [VerfasserIn] |
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| | Zhang, Tingting [VerfasserIn] |
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| | Gianno, Francesca [VerfasserIn] |
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| | Giangaspero, Felice [VerfasserIn] |
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| | Hassan, Bassem A. [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Tiberi, Luca [VerfasserIn] |
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| Titel: | Notch1 switches progenitor competence in inducing medulloblastoma |
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| Verf.angabe: | Claudio Ballabio, Matteo Gianesello, Chiara Lago, Konstantin Okonechnikov, Marica Anderle, Giuseppe Aiello, Francesco Antonica, Tingting Zhang, Francesca Gianno, Felice Giangaspero, Bassem A. Hassan, Stefan M. Pfister, Luca Tiberi |
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| E-Jahr: | 2021 |
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| Jahr: | 23 Jun 2021 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 19.07.2022 |
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| Titel Quelle: | Enthalten in: Science advances |
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| Ort Quelle: | Washington, DC [u.a.] : Assoc., 2015 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 7(2021), 26, Artikel-ID eabd2781, Seite 1-13 |
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| ISSN Quelle: | 2375-2548 |
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| Abstract: | The identity of the cell of origin is a key determinant of cancer subtype, progression, and prognosis. Group 3 medulloblastoma (MB) is a malignant childhood brain cancer with poor prognosis and few candidates as putative cell of origin. We overexpressed the group 3 MB genetic drivers MYC and Gfi1 in different candidate cells of origin in the postnatal mouse cerebellum. We found that S100b(+) cells are competent to initiate group 3 MB, and we observed that S100b(+) cells have higher levels of Notch1 pathway activity compared to Math1(+) cells. We found that additional activation of Notch1 in Math1(+) and Sox2(+) cells was sufficient to induce group 3 MB upon MYC/Gfi1 expression. Together, our data suggest that the Notch1 pathway plays a critical role in group 3 MB initiation. |
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| DOI: | doi:10.1126/sciadv.abd2781 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1126/sciadv.abd2781 |
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| | Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1126%2Fsciadv.abd278 ... |
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| | DOI: https://doi.org/10.1126/sciadv.abd2781 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | activation |
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| | cells |
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| | driven |
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| | growth |
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| | models |
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| | neurogenesis |
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| | signaling pathway |
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| | stem |
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| | subgroup |
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| | target |
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| K10plus-PPN: | 1810824133 |
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| Verknüpfungen: | → Zeitschrift |
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Notch1 switches progenitor competence in inducing medulloblastoma / Ballabio, Claudio [VerfasserIn]; 23 Jun 2021 (Online-Ressource)
