| |  Online-Ressource |
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| Verfasst von: | Faßbender, Klaus [VerfasserIn]  |
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| | Fatar, Marc [VerfasserIn] |
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| | Ragoschke-Schumm, Andreas [VerfasserIn] |
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| | Picard, Martin [VerfasserIn] |
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| | Bertsch, Thomas [VerfasserIn] |
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| | Kühl, Sandra [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| Titel: | Subacute but not acute generation of nitric oxide in focal cerebral ischemia |
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| Verf.angabe: | K. Fassbender, M. Fatar, A. Ragoschke, M. Picard, T. Bertsch, S. Kuehl, M. Hennerici |
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| E-Jahr: | 2000 |
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| Jahr: | 1 September 2000 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 19.07.2022 |
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| Titel Quelle: | Enthalten in: Stroke |
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| Ort Quelle: | New York, NY : Association, 1970 |
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| Jahr Quelle: | 2000 |
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| Band/Heft Quelle: | 31(2000), 9, Seite 2208-2211 |
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| ISSN Quelle: | 1524-4628 |
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| Abstract: | BACKGROUND AND PURPOSE: Excessive release of nitric oxide (NO) has been implicated in the pathophysiology of neurodegeneration in ischemic stroke. We compared intracerebral release of indicators of NO generation at the acute and subacute stages of transient focal cerebral ischemia. - METHODS: In vivo microdialysis in the rat striatum was performed at the acute (first hours) and subacute (after 24 or 48 hours) stages of cerebral ischemia or sham operation to monitor intracerebral release of the stable NO metabolites nitrite and nitrate. - RESULTS: Whereas only a nonsignificant trend toward increased release of these NO metabolites was evidenced in acute cerebral ischemia, a significant NO generation was observed subacutely, 48 hours after induction of cerebral ischemia. Aminoguanidine, a selective inhibitor of inducible NO synthase, suppressed this delayed release of nitrite and nitrate. - CONCLUSIONS: Whereas these observations do not support a major NO generation in acute cerebral ischemia, they indicate an inducible NO synthase-dependent NO generation predominantly at the subacute phase of ischemic neurodegeneration. Therefore, NO generation may play a pathophysiological role in delayed ischemic neurodegeneration. |
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| DOI: | doi:10.1161/01.str.31.9.2208 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1161/01.str.31.9.2208 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Animals |
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| | Brain Ischemia |
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| | Corpus Striatum |
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| | Enzyme Inhibitors |
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| | Guanidines |
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| | Microdialysis |
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| | Nerve Degeneration |
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| | Nitrates |
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| | Nitric Oxide |
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| | Nitric Oxide Synthase |
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| | Nitric Oxide Synthase Type II |
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| | Nitrites |
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| | Rats |
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| | Time Factors |
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| K10plus-PPN: | 1810845696 |
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| Verknüpfungen: | → Zeitschrift |
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Subacute but not acute generation of nitric oxide in focal cerebral ischemia / Faßbender, Klaus [VerfasserIn]; 1 September 2000 (Online-Ressource)
