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| Verfasst von: | Höper, Marius [VerfasserIn]  |
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| | Pausch, Christine [VerfasserIn] |
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| | Grünig, Ekkehard [VerfasserIn] |
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| | Staehler, Gerd [VerfasserIn] |
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| | Huscher, Doerte [VerfasserIn] |
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| | Pittrow, David [VerfasserIn] |
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| | Olsson, Karen M. [VerfasserIn] |
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| | Vizza, Carmine Dario [VerfasserIn] |
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| | Gall, Henning [VerfasserIn] |
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| | Distler, Oliver [VerfasserIn] |
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| | Opitz, Christian [VerfasserIn] |
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| | Gibbs, J. Simon R. [VerfasserIn] |
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| | Delcroix, Marion [VerfasserIn] |
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| | Ghofrani, H. Ardeschir [VerfasserIn] |
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| | Rosenkranz, Stephan [VerfasserIn] |
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| | Park, Da-Hee [VerfasserIn] |
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| | Ewert, Ralf [VerfasserIn] |
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| | Kaemmerer, Harald [VerfasserIn] |
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| | Lange, Tobias J. [VerfasserIn] |
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| | Kabitz, Hans-Joachim [VerfasserIn] |
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| | Skowasch, Dirk [VerfasserIn] |
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| | Skride, Andris [VerfasserIn] |
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| | Claussen, Martin [VerfasserIn] |
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| | Behr, Juergen [VerfasserIn] |
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| | Milger, Katrin [VerfasserIn] |
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| | Halank, Michael [VerfasserIn] |
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| | Wilkens, Heinrike [VerfasserIn] |
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| | Seyfarth, Hans-Jürgen [VerfasserIn] |
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| | Held, Matthias [VerfasserIn] |
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| | Dumitrescu, Daniel [VerfasserIn] |
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| | Tsangaris, Iraklis [VerfasserIn] |
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| | Vonk-Noordegraaf, Anton [VerfasserIn] |
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| | Ulrich, Silvia [VerfasserIn] |
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| | Klose, Hans [VerfasserIn] |
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| Titel: | Temporal trends in pulmonary arterial hypertension |
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| Titelzusatz: | results from the COMPERA registry |
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| Verf.angabe: | Marius M. Hoeper, Christine Pausch, Ekkehard Grünig, Gerd Staehler, Doerte Huscher, David Pittrow, Karen M. Olsson, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, J. Simon R. Gibbs, Marion Delcroix, H. Ardeschir Ghofrani, Stephan Rosenkranz, Da-Hee Park, Ralf Ewert, Harald Kaemmerer, Tobias J. Lange, Hans-Joachim Kabitz, Dirk Skowasch, Andris Skride, Martin Claussen, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Jürgen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich and Hans Klose |
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| E-Jahr: | 2022 |
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| Jahr: | June 2, 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 21.07.2022 |
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| Titel Quelle: | Enthalten in: The European respiratory journal |
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| Ort Quelle: | Lausanne : ERS, 1988 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 59(2022), 6, Artikel-ID 2102024, Seite 1-13 |
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| ISSN Quelle: | 1399-3003 |
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| Abstract: | Background Since 2015, the European pulmonary hypertension guidelines recommend the use of combination therapy in most patients with pulmonary arterial hypertension (PAH). However, it is unclear to what extent this treatment strategy is adopted in clinical practice and if it is associated with improved long-term survival. - Methods We analysed data from COMPERA, a large European pulmonary hypertension registry, to assess temporal trends in the use of combination therapy and survival of patients with newly diagnosed PAH between 2010 and 2019. For survival analyses, we looked at annualised data and at cumulated data comparing the periods 2010-2014 and 2015-2019. - Results A total of 2531 patients were included. The use of early combination therapy (within 3 months after diagnosis) increased from 10.0% in patients diagnosed with PAH in 2010 to 25.0% in patients diagnosed with PAH in 2019. The proportion of patients receiving combination therapy 1 year after diagnosis increased from 27.7% to 46.3%. When comparing the 2010-2014 and 2015-2019 periods, 1-year survival estimates were similar (89.0% (95% CI 87.2-90.9%) and 90.8% (95% CI 89.3-92.4%), respectively), whereas there was a slight but nonsignificant improvement in 3-year survival estimates (67.8% (95% CI 65.0-70.8%) and 70.5% (95% CI 67.8-73.4%), respectively). - Conclusions The use of combination therapy increased from 2010 to 2019, but most patients still received monotherapy. Survival rates at 1 year after diagnosis did not change over time. Future studies need to determine if the observed trend suggesting improved 3-year survival rates can be confirmed. - Tweetable abstract @ERSpublications - click to tweetIn this analysis of temporal trends in PAH treatment patterns and survival in 2010-2019, this study found an increase in the use of targeted combination therapies but only a slight, nonsignificant trend towards improved survival 3 years after diagnosis https://bit.ly/3FExlK5 |
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| DOI: | doi:10.1183/13993003.02024-2021 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1183/13993003.02024-2021 |
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| | Volltext: https://erj.ersjournals.com/content/59/6/2102024 |
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| | DOI: https://doi.org/10.1183/13993003.02024-2021 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1811137512 |
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| Verknüpfungen: | → Zeitschrift |
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Temporal trends in pulmonary arterial hypertension / Höper, Marius [VerfasserIn]; June 2, 2022 (Online-Ressource)
