| |  Online-Ressource |
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| Verfasst von: | Schümann, Franziska Lea [VerfasserIn]  |
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| | Groß, Elisabeth [VerfasserIn] |
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| | Bauer, Marcus [VerfasserIn] |
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| | Rohde, Christian [VerfasserIn] |
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| | Sandmann, Sarah [VerfasserIn] |
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| | Terziev, Denis [VerfasserIn] |
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| | Müller, Lutz P. [VerfasserIn] |
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| | Posern, Guido [VerfasserIn] |
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| | Wienke, Andreas [VerfasserIn] |
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| | Fend, Falko [VerfasserIn] |
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| | Hansmann, Martin-Leo [VerfasserIn] |
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| | Klapper, Wolfram [VerfasserIn] |
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| | Rosenwald, Andreas [VerfasserIn] |
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| | Stein, Harald [VerfasserIn] |
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| | Dugas, Martin [VerfasserIn] |
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| | Müller-Tidow, Carsten [VerfasserIn] |
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| | Wickenhauser, Claudia [VerfasserIn] |
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| | Binder, Mascha [VerfasserIn] |
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| | Weber, Thomas [VerfasserIn] |
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| Titel: | Divergent effects of EZH1 and EZH2 protein expression on the prognosis of patients with T-cell lymphomas |
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| Verf.angabe: | Franziska Lea Schümann, Elisabeth Groß, Marcus Bauer, Christian Rohde, Sarah Sandmann, Denis Terziev, Lutz P. Müller, Guido Posern, Andreas Wienke, Falko Fend, Martin-Leo Hansmann, Wolfram Klapper, Andreas Rosenwald, Harald Stein, Martin Dugas, Carsten Müller-Tidow, Claudia Wickenhauser, Mascha Binder, Thomas Weber |
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| E-Jahr: | 2021 |
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| Jahr: | 5 December 2021 |
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| Umfang: | 16 S. |
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| Fussnoten: | Gesehen am 21.07.2022 |
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| Titel Quelle: | Enthalten in: Biomedicines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 9(2021), 12, Artikel-ID 1842, Seite 1-16 |
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| ISSN Quelle: | 2227-9059 |
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| Abstract: | T-cell lymphomas are highly heterogeneous and their prognosis is poor under the currently available therapies. Enhancers of zeste homologue 1 and 2 (EZH1/2) are histone H3 lysine-27 trimethyltransferases (H3K27me3). Despite the rapid development of new drugs inhibiting EZH2 and/or EZH1, the molecular interplay of these proteins and the impact on disease progression and prognosis of patients with T-cell lymphomas remains insufficiently understood. In this study, EZH1/2 mutation status was evaluated in 33 monomorphic epitheliotropic intestinal T-cell lymphomas by next generation sequencing and EZH1/2 and H3K27me3 protein expression levels were detected by immunohistochemistry in 46 T-cell lymphomas. Correlations with clinicopathologic features were analyzed and survival curves generated. No EZH1 mutations and one (3%) EZH2 missense mutation were identified. In univariable analysis, high EZH1 expression was associated with an improved overall survival (OS) and progression-free survival (PFS) whereas high EZH2 and H3K27me3 expression were associated with poorer OS and PFS. Multivariable analysis revealed EZH1 (hazard ratio (HR) = 0.183; 95% confidence interval (CI): 0.044-0.767; p = 0.020;) and EZH2 (HR = 8.245; 95% CI: 1.898-35.826; p = 0.005) to be independent, divergent prognostic markers for OS. In conclusion, EZH1/2 protein expression had opposing effects on the prognosis of T-cell lymphoma patients. |
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| DOI: | doi:10.3390/biomedicines9121842 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Resolving-System: https://doi.org/10.3390/biomedicines9121842 |
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| | kostenfrei: Resolving-System: https://www.mdpi.com/2227-9059/9/12/1842 |
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| | DOI: https://doi.org/10.3390/biomedicines9121842 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | epigenetics |
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| | EZH1 |
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| | EZH2 |
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| | H3K27me3 |
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| | immunohistochemistry |
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| | next generation sequencing |
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| | PTCL |
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| | T-cell non-Hodgkin’s lymphomas |
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| K10plus-PPN: | 1811291864 |
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| Verknüpfungen: | → Zeitschrift |
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Divergent effects of EZH1 and EZH2 protein expression on the prognosis of patients with T-cell lymphomas / Schümann, Franziska Lea [VerfasserIn]; 5 December 2021 (Online-Ressource)
