| |  Online-Ressource |
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| Verfasst von: | Demircan, Kamil [VerfasserIn]  |
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| | Chillon, Thilo Samson [VerfasserIn] |
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| | Sun, Qian [VerfasserIn] |
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| | Heller, Raban [VerfasserIn] |
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| | Klingenberg, Georg Jochen [VerfasserIn] |
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| | Hirschbil-Bremer, Ines Maria [VerfasserIn] |
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| | Seemann, Petra [VerfasserIn] |
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| | Diegmann, Joachim [VerfasserIn] |
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| | Bachmann, Manuel [VerfasserIn] |
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| | Moghaddam-Alvandi, Arash [VerfasserIn] |
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| | Schomburg, Lutz [VerfasserIn] |
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| Titel: | Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status |
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| Verf.angabe: | Kamil Demircan, Thilo Samson Chillon, Qian Sun, Raban Arved Heller, Georg Jochen Klingenberg, Ines Maria Hirschbil-Bremer, Petra Seemann, Joachim Diegmann, Manuel Bachmann, Arash Moghaddam, Lutz Schomburg |
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| E-Jahr: | 2022 |
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| Jahr: | 3 February 202 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 25.07.2022 |
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| Titel Quelle: | Enthalten in: Redox Biology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 50(2022), Artikel-ID 102242, Seite 1-7 |
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| ISSN Quelle: | 2213-2317 |
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| Abstract: | The essential trace element selenium (Se) is of central importance for human health and particularly for a regular functioning of the immune system. In the context of the current pandemic, Se deficiency in patients with COVID19 correlated with disease severity and mortality risk. Selenium has been reported to be associated with the immune response following vaccination, but it is unknown whether this also applies to SARS-CoV-2 vaccines. In this observational study, adult health care workers (n = 126) who received two consecutive anti-SARS-CoV-2 vaccinations by BNT162b2 were followed for up to 24 weeks, with blood samples collected at the first and second dose and at three and 21 weeks after the second dose. Serum SARS-CoV-2 IgG titres, neutralising antibody potency, total Se and selenoprotein P concentrations, and glutathione peroxidase 3 activity were quantified. All three biomarkers of Se status were significantly correlated at all the time points, and participants who reported supplemental Se intake displayed higher Se concentrations. SARS-CoV-2 IgG titres and neutralising potency were highest three weeks after the second dose and decreased towards the last sampling point. The humoral immune response was not related to any of the three Se status biomarkers. Supplemental Se intake had no effect at any time point on the vaccination response as measured by serum SARS-CoV-2 IgG levels or neutralising potency. Overall, no association was found between Se status or supplemental Se intake and humoral immune response to COVID-19 mRNA vaccination. |
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| DOI: | doi:10.1016/j.redox.2022.102242 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.redox.2022.102242 |
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| | Volltext: https://www.webofscience.com/api/gateway?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.1016%2Fj.redox.2022.102242&D ... |
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| | DOI: https://doi.org/10.1016/j.redox.2022.102242 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Antibody |
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| | biomarkers |
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| | Cohort study |
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| | disease |
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| | Glutathione peroxidase |
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| | mortality |
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| | pregnant-women |
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| | risk |
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| | SARS-CoV-2 |
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| | selenoprotein p |
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| | supplementation |
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| | Vaccine |
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| K10plus-PPN: | 1811494153 |
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| Verknüpfungen: | → Zeitschrift |
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Humoral immune response to COVID-19 mRNA vaccination in relation to selenium status / Demircan, Kamil [VerfasserIn]; 3 February 202 (Online-Ressource)
