Time course and reaction types of serum IGF-1 and its relationship to BMI and leptin regarding inpatients with anorexia nervosa

• Verfasst von: Hellwig-Walter, Christiane [VerfasserIn]
• Verfasst von: Brune, Maik [VerfasserIn]
• Verfasst von: Schellberg, Dieter [VerfasserIn]
• Verfasst von: Buckert, Magdalena [VerfasserIn]
• Verfasst von: Wesche, Daniela [VerfasserIn]
• Verfasst von: Cuntz, Ulrich [VerfasserIn]
• Verfasst von: Friederich, Hans-Christoph [VerfasserIn]
• Verfasst von: Wild, Beate [VerfasserIn]
• Titel: Time course and reaction types of serum IGF-1 and its relationship to BMI and leptin regarding inpatients with anorexia nervosa
• Verf.angabe: Christiane Hellwig-Walter, Maik Brune, Dieter Schellberg, Magdalena Buckert, Daniela Wesche, Ulrich Cuntz, Hans-Christoph Friederich, Beate Wild
• E-Jahr: 2022
• Jahr: 31 May 2022
• Umfang: 5 S.
• Fussnoten: Gesehen am 27.07.2022
• Titel Quelle: Enthalten in: Growth hormone & IGF research
• Ort Quelle: Burlington, Mass. [u.a.] : Harcourt, 1998
• Jahr Quelle: 2022
• Band/Heft Quelle: 64(2022) vom: Juni, Artikel-ID 101470, Seite 1-5
• ISSN Quelle: 1532-2238
• DOI: doi:10.1016/j.ghir.2022.101470
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Anorexia nervosa
• Sach-SW: Hormonal reaction type
• Sach-SW: IGF-I
• Sach-SW: Individual growth models
• Sach-SW: Leptin
• K10plus-PPN: 1811794629

Abstract

Objective - Anorexia nervosa (AN) is a severe mental disorder that is characterized by restriction of energy intake, low weight, and endocrine abnormalities. One of the known endocrine changes in relation to underweight is in the GH/IGF-I axis. The aim of the study was (a) to investigate longitudinal characteristics of the IGF-I-change during therapy and weight gain in adult AN, (b) to determine relationships between IGF-I and leptin, (c) to characterize patients with weak and pronounced hormonal reactions to underweight. - Design - Data was assessed from 19 AN patients. Over the first two months, serum IGF-I concentrations were assessed on a weekly basis; thereafter on a monthly basis. The trend of IGF-I values over time was analyzed using individual growth models. - Results - In total, n = 177 IGF-I measurements were analyzed. IGF-I increased significantly dependent on BMI (slope = 20.81, p < 0.001), not modulated by duration of disease. The increase in IGF-I was significantly related to the increase in leptin concentrations over time (slope = 15.57, p < 0.001). Patients with a weaker hormonal reaction to underweight were significantly older compared to patients with a pronounced hormonal reaction (t(17) = 3.07, p = 0.007). - Conclusions - During treatment, IGF-I change is clearly related to BMI as well as to leptin. Age appears to be associated with the IGF-I response to underweight.