| |  Online-Ressource |
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| Verfasst von: | Faßbender, Klaus [VerfasserIn]  |
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| | Mielke, Orell [VerfasserIn] |
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| | Bertsch, Thomas [VerfasserIn] |
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| | Muehlhauser, F. [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| | Kurimoto, M. [VerfasserIn] |
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| | Rossol, Siegbert [VerfasserIn] |
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| Titel: | Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases |
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| Verf.angabe: | K. Fassbender, O. Mielke, T. Bertsch, F. Muehlhauser, M. Hennerici, M. Kurimoto, and S. Rossol |
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| E-Jahr: | 1999 |
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| Jahr: | September 1, 1999 |
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| Umfang: | 3 S. |
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| Fussnoten: | Gesehen am 27.07.2022 |
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| Titel Quelle: | Enthalten in: Neurology |
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| Ort Quelle: | Philadelphia, Pa. : Wolters Kluwer, 1951 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 53(1999), 5, Seite 1104-1106 |
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| ISSN Quelle: | 1526-632X |
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| Abstract: | OBJECTIVE: To examine the intrathecal production of a newly identified cytokine, interferon-gamma-inducing factor (IL-18), together with interferon-gamma itself, in inflammatory diseases of the CNS (i.e., bacterial meningitis, viral meningoencephalitis, and MS). - RESULTS: IL-18 concentrations in CSF were significantly increased in bacterial meningitis and tended toward increased levels in viral meningoencephalitis. In contrast, IL-18 was detectable only in a few patients with MS and healthy controls. Interestingly, interferon-gamma was significantly increased selectively in CSF of patients with viral meningoencephalitis. - CONCLUSION: The observation of an intrathecal release of IL-18 in patients with meningitis argues for a pathophysiologic role of this novel cytokine in immunity against invading microorganisms the CNS. |
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| DOI: | doi:10.1212/wnl.53.5.1104 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1212/wnl.53.5.1104 |
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| | DOI: https://doi.org/10.1212/wnl.53.5.1104 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aged |
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| | Aged, 80 and over |
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| | Central Nervous System Diseases |
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| | Female |
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| | Humans |
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| | Inflammation |
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| | Interferon-gamma |
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| | Interleukin-18 |
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| | Male |
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| | Meningitis, Bacterial |
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| | Meningoencephalitis |
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| | Middle Aged |
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| | Multiple Sclerosis |
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| K10plus-PPN: | 1811810926 |
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| Verknüpfungen: | → Zeitschrift |
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Interferon-γ-inducing factor (IL-18) and interferon-γ in inflammatory CNS diseases / Faßbender, Klaus [VerfasserIn]; September 1, 1999 (Online-Ressource)
