| |  Online-Ressource |
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| Verfasst von: | Faßbender, Klaus [VerfasserIn]  |
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| | Bertsch, Thomas [VerfasserIn] |
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| | Mielke, Orell [VerfasserIn] |
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| | Mühlhauser, Frank [VerfasserIn] |
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| | Hennerici, Michael G. [VerfasserIn] |
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| Titel: | Adhesion molecules in cerebrovascular diseases |
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| Titelzusatz: | evidence for an inflammatory endothelial activation in cerebral large- and small-vessel disease |
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| Verf.angabe: | Klaus Fassbender, Thomas Bertsch, Orell Mielke, Frank Mühlhauser, and Michael Hennerici |
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| E-Jahr: | 1999 |
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| Jahr: | 1 August 1999 |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 28.07.2022 |
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| Titel Quelle: | Enthalten in: Stroke |
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| Ort Quelle: | New York, NY : Association, 1970 |
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| Jahr Quelle: | 1999 |
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| Band/Heft Quelle: | 30(1999), 8, Seite 1647-1650 |
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| ISSN Quelle: | 1524-4628 |
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| Abstract: | BACKGROUND AND PURPOSE: Adhesion molecules mediate attachment and transendothelial migration of leukocytes as a critical step in pathogenesis of atherosclerosis. Their expression and release were comparatively investigated in patients with large- and small-vessel disease of the central nervous system. - METHODS: With immunological methods, serum concentrations of endothelial-derived adhesion molecules (soluble endothelial-leukocyte adhesion molecule [sE-selectin], soluble vascular-leukocyte adhesion molecule-1, and soluble intercellular adhesion molecule-1 [sICAM-1]) were quantified in patients with obstructive disease of extracranial (n=89) and intracranial (n=20) large-vessel disease and patients with subcortical vascular encephalopathy (n=64), a cerebral small-vessel disease. As controls, age- and sex-matched subjects without obstructive cerebrovascular disease (n=67) were studied. - RESULTS: We observed significantly increased serum concentrations of sE-selectin and sICAM-1 in patients with both obstructive disease of the large brain-supplying arteries and subcortical vascular encephalopathy. Interestingly, the highest levels were observed in intracranial macroangiopathy. Furthermore, concentrations of sICAM-1 and sE-selectin were significantly increased in current smokers but not in diabetic or hypertensive patients. - CONCLUSIONS: The observation of elevated release of endothelial-derived adhesion molecules in both patients with stenoses of the large brain-supplying arteries and patients with subcortical vascular encephalopathy indicates that inflammatory endothelial activation and adhesion of leukocytes play similarly important roles in cerebral large- and small-vessel disease. |
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| DOI: | doi:10.1161/01.str.30.8.1647 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
DOI: https://doi.org/10.1161/01.str.30.8.1647 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aged |
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| | Aged, 80 and over |
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| | Arterial Occlusive Diseases |
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| | Biomarkers |
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| | Brain |
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| | Brain Ischemia |
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| | E-Selectin |
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| | Female |
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| | Follow-Up Studies |
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| | Humans |
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| | Intercellular Adhesion Molecule-1 |
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| | Magnetic Resonance Imaging |
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| | Male |
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| | Middle Aged |
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| | Risk Factors |
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| | Spectrophotometry |
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| | Tomography, X-Ray Computed |
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| | Ultrasonography, Doppler, Transcranial |
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| K10plus-PPN: | 1811908446 |
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| Verknüpfungen: | → Zeitschrift |
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Adhesion molecules in cerebrovascular diseases / Faßbender, Klaus [VerfasserIn]; 1 August 1999 (Online-Ressource)
