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Verfasst von:Faßbender, Klaus [VerfasserIn]   i
 Dempfle, Carl-Erik [VerfasserIn]   i
 Mielke, Orell [VerfasserIn]   i
 Schwartz, Andreas [VerfasserIn]   i
 Daffertshofer, Michael [VerfasserIn]   i
 Eschenfelder, Christoph C. [VerfasserIn]   i
 Dollman, Martina [VerfasserIn]   i
 Hennerici, Michael G. [VerfasserIn]   i
Titel:Changes in coagulation and fibrinolysis markers in acute ischemic stroke treated with recombinant tissue plasminogen activator
Verf.angabe:Klaus Fassbender, Carl-Erik Dempfle, Orell Mielke, Andreas Schwartz, Michael Daffertshofer, Christoph Eschenfelder, Martina Dollman, Michael Hennerici
E-Jahr:1999
Jahr:1 October 1999
Umfang:4 S.
Fussnoten:Gesehen am 28.07.2022
Titel Quelle:Enthalten in: Stroke
Ort Quelle:New York, NY : Association, 1970
Jahr Quelle:1999
Band/Heft Quelle:30(1999), 10, Seite 2101-2104
ISSN Quelle:1524-4628
Abstract:BACKGROUND AND PURPOSE: Shifts of the balance between coagulation and fibrinolysis play a crucial role in pathogenesis and treatment of cerebral ischemia. In this study, we characterized the kinetics of hemostatic abnormalities induced by acute ischemic stroke and its thrombolytic (recombinant tissue plasminogen activator [rtPA]) or anticoagulant (heparin) treatment. - METHODS: Systemic generation of molecular markers of hemostasis (fibrin monomer, D-dimer, thrombin-antithrombin complex, and fibrinopeptide 1.2) was monitored in acute ischemic stroke, and the effects of thrombolytic and anticoagulant treatments were analyzed. - RESULTS: Thrombolysis with rtPA induced a massive response of markers of coagulation activation and fibrin formation that peaked after 1 to 3 hours and persisted for up to 72 hours. In contrast, only minor hemostatic changes were induced by acute ischemic stroke itself. Administration of heparin did not significantly affect these hemostatic abnormalities. - CONCLUSIONS: This first characterization of the coagulation activation induced by rtPA treatment for acute ischemic stroke and the failure to abolish such hemostatic abnormalities by heparin may be of value for further refinement of the currently discussed thrombolytic therapy and the controversial adjunctive anticoagulant prophylaxis in stroke patients.
DOI:doi:10.1161/01.STR.30.10.2101
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1161/01.STR.30.10.2101
 DOI: https://doi.org/10.1161/01.STR.30.10.2101
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Aged
 Aged, 80 and over
 Anticoagulants
 Biomarkers
 Blood Coagulation
 Female
 Fibrinolysis
 Fibrinolytic Agents
 Heparin
 Humans
 Ischemic Attack, Transient
 Male
 Recombinant Proteins
 Risk Factors
 Tissue Plasminogen Activator
K10plus-PPN:181193188X
Verknüpfungen:→ Zeitschrift

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