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Verfasst von:Hoffmann, Katrin [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Schemmer, Peter [VerfasserIn]   i
Titel:Supplementation of amino acids to prevent reperfusion injury after liver surgery and transplantation
Titelzusatz:where do we stand today?
Verf.angabe:Katrin Hoffmann, Markus W. Büchler, Peter Schemmer
E-Jahr:2011
Jahr:[April 2011]
Umfang:5 S.
Fussnoten:Gesehen am 29.07.2022
Titel Quelle:Enthalten in: Clinical nutrition
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1982
Jahr Quelle:2011
Band/Heft Quelle:30(2011), 2, Seite 143-147
ISSN Quelle:1532-1983
Abstract:Background & aims - Functional liver failure remains one of the major complications after liver surgery. Ischemia/reperfusion injury (IRI) is strongly associated with increased morbidity and mortality after liver resection and transplantation. An ischemia induced activation of Kupffer cells with subsequent release of toxic mediators leads to disturbance of intrahepatic microcirculation, increased oxygen consumption of the liver and depletion of hepatic glycogen reserves. Aim of this review was to summarize the evidence for prevention of IRI by amino acid supplement and to give an overview on potential clinical use in liver surgery. - Methods - A systematic literature search (Medline, Embase, and The Cochrane Central Register of Controlled Trials) was performed to identify the relevant literature. - Results - Amino acid supplement has hepatoprotective effects and is non-toxic. Up to now heterogenic results have been reported from clinical trials. However, positive effects on microcirculation, leukoycte-endothelial interaction, Kupffer cells and pro-inflammatory mediator release have been described in trials investigating glycine supplementation. The data for N-acetylcysteine remain heterogenic. - Conclusion - An effective protection against IRI by amino acid supplementation has been demonstrated in experimental and several clinical studies. However, further clinical trials are warranted to identify the most promising approach for a routine clinical application.
DOI:doi:10.1016/j.clnu.2010.09.006
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.clnu.2010.09.006
 Volltext: https://www.sciencedirect.com/science/article/pii/S0261561410001792
 DOI: https://doi.org/10.1016/j.clnu.2010.09.006
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Amino acids
 Ischemia/reperfusion injury
 Kupffer cells
 Liver surgery
K10plus-PPN:181199783X
Verknüpfungen:→ Zeitschrift

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