| |  Online-Ressource |
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| Verfasst von: | Deng, Qu [VerfasserIn]  |
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| | Natesan, Ramakrishnan [VerfasserIn] |
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| | Cidre-Aranaz, Florencia [VerfasserIn] |
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| | Arif, Shehbeel [VerfasserIn] |
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| | Liu, Ying [VerfasserIn] |
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| | Rasool, Reyaz ur [VerfasserIn] |
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| | Wang, Pei [VerfasserIn] |
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| | Mitchell-Velasquez, Erick [VerfasserIn] |
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| | Das, Chandan Kanta [VerfasserIn] |
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| | Vinca, Endrit [VerfasserIn] |
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| | Cramer, Zvi [VerfasserIn] |
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| | Grohar, Patrick J. [VerfasserIn] |
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| | Chou, Margaret [VerfasserIn] |
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| | Kumar-Sinha, Chandan [VerfasserIn] |
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| | Weber, Kristy [VerfasserIn] |
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| | Eisinger-Mathason, T. S. Karin [VerfasserIn] |
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| | Grillet, Nicolas [VerfasserIn] |
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| | Grünewald, Thomas G. P. [VerfasserIn] |
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| | Asangani, Irfan A. [VerfasserIn] |
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| Titel: | Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1 |
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| Verf.angabe: | Qu Deng, Ramakrishnan Natesan, Florencia Cidre-Aranaz, Shehbeel Arif, Ying Liu, Reyaz ur Rasool, Pei Wang, Erick Mitchell-Velasquez, Chandan Kanta Das, Endrit Vinca, Zvi Cramer, Patrick J. Grohar, Margaret Chou, Chandan Kumar-Sinha, Kristy Weber, T.S. Karin Eisinger-Mathason, Nicolas Grillet, Thomas G.P. Grünewald, Irfan A. Asangani |
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| E-Jahr: | 2022 |
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| Jahr: | 14 June 2022 |
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| Umfang: | 26 S. |
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| Fussnoten: | Gesehen am 03.08.2022 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 39(2022), 11, Artikel-ID 110971, Seite 1-26 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Ewing sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1::FLI1 transcription factor drives EwS by orchestrating an oncogenic transcription program through de novo enhancers. By integrative analysis of thousands of transcriptomes representing pan-cancer cell lines, primary cancers, metastasis, and normal tissues, we identify a 32-gene signature (ESS32 [Ewing Sarcoma Specific 32]) that stratifies EwS from pan-cancer. Among the ESS32, LOXHD1, encoding a stereociliary protein, is the most highly expressed gene through an alternative transcription start site. Deletion or silencing of EWSR1::FLI1 bound upstream de novo enhancer results in loss of the LOXHD1 short isoform, altering EWSR1::FLI1 and HIF1α pathway genes and resulting in decreased proliferation/invasion of EwS cells. These observations implicate LOXHD1 as a biomarker and a determinant of EwS metastasis and suggest new avenues for developing LOXHD1-targeted drugs or cellular therapies for this deadly disease. |
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| DOI: | doi:10.1016/j.celrep.2022.110971 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.celrep.2022.110971 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S2211124722007574 |
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| | DOI: https://doi.org/10.1016/j.celrep.2022.110971 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | biomarker |
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| | enhancer |
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| | Ewing sarcoma |
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| | EWSR1::FLI1 |
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| | hypoxia |
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| | integrative genomics |
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| | LOXHD1 |
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| | metastasis |
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| | transcription |
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| K10plus-PPN: | 1813090432 |
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| Verknüpfungen: | → Zeitschrift |
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Oncofusion-driven de novo enhancer assembly promotes malignancy in Ewing sarcoma via aberrant expression of the stereociliary protein LOXHD1 / Deng, Qu [VerfasserIn]; 14 June 2022 (Online-Ressource)
