| |  Online-Ressource |
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| Verfasst von: | Kihm, Lars Philipp [VerfasserIn]  |
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| | Müller-Krebs, Sandra [VerfasserIn] |
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| | Klein, Julia [VerfasserIn] |
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| | Ehrlich, Gregory Marius [VerfasserIn] |
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| | Mertes, Laura [VerfasserIn] |
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| | Groß-Weissmann, Marie-Luise [VerfasserIn] |
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| | Adaikalakoteswari, Antonysunil [VerfasserIn] |
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| | Thornalley, Paul J. [VerfasserIn] |
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| | Hammes, Hans-Peter [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Zeier, Martin [VerfasserIn] |
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| | Schwenger, Vedat [VerfasserIn] |
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| Titel: | Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis |
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| Verf.angabe: | Lars P. Kihm, Sandra Müller-Krebs, Julia Klein, Gregory Ehrlich, Laura Mertes, Marie-Luise Gross, Antonysunil Adaikalakoteswari, Paul J. Thornalley, Hans-Peter Hammes, Peter P. Nawroth, Martin Zeier, and Vedat Schwenger |
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| E-Jahr: | 2011 |
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| Jahr: | April 29, 2011 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 04.08.2022 |
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| Titel Quelle: | Enthalten in: American Society of NephrologyJournal of the American Society of Nephrology |
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| Ort Quelle: | Washington, DC : American Society of Nephrology, 1990 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 22(2011), 5, Seite 914-926 |
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| ISSN Quelle: | 1533-3450 |
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| Abstract: | Residual renal function and the integrity of the peritoneal membrane contribute to morbidity and mortality among patients treated with peritoneal dialysis. Glucose and its degradation products likely contribute to the deterioration of the remnant kidney and damage to the peritoneum. Benfotiamine decreases glucose-induced tissue damage, suggesting the potential for benefit in peritoneal dialysis. Here, in a model of peritoneal dialysis in uremic rats, treatment with benfotiamine decreased peritoneal fibrosis, markers of inflammation, and neovascularization, resulting in improved characteristics of peritoneal transport. Furthermore, rats treated with benfotiamine exhibited lower expression of advanced glycation endproducts and their receptor in the peritoneum and the kidney, reduced glomerular and tubulointerstitial damage, and less albuminuria. Increased activity of transketolase in tissue and blood contributed to the protective effects of benfotiamine. In primary human peritoneal mesothelial cells, the addition of benfotiamine led to enhanced transketolase activity and decreased expression of advanced glycation endproducts and their receptor. Taken together, these data suggest that benfotiamine protects the peritoneal membrane and remnant kidney in a rat model of peritoneal dialysis and uremia. |
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| DOI: | doi:10.1681/ASN.2010070750 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1681/ASN.2010070750 |
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| | Volltext: https://jasn.asnjournals.org/content/22/5/914 |
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| | DOI: https://doi.org/10.1681/ASN.2010070750 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis. - 2011 |
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| K10plus-PPN: | 1813209227 |
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| Verknüpfungen: | → Zeitschrift |
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Benfotiamine protects against peritoneal and kidney damage in peritoneal dialysis / Kihm, Lars Philipp [VerfasserIn]; April 29, 2011 (Online-Ressource)
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