Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Rössler, Ingrid [VerfasserIn]   i
 Weigl, Sarah [VerfasserIn]   i
 Fernández-Fernández, José [VerfasserIn]   i
 Martín-Villanueva, Sara [VerfasserIn]   i
 Strauß, Daniela [VerfasserIn]   i
 Hurt, Ed [VerfasserIn]   i
 Cruz, Jesús de la [VerfasserIn]   i
 Pertschy, Brigitte [VerfasserIn]   i
Titel:The C-terminal tail of ribosomal protein Rps15 is engaged in cytoplasmic pre-40S maturation
Verf.angabe:Ingrid Rössler, Sarah Weigl, José Fernández-Fernández, Sara Martín-Villanueva, Daniela Strauss, Ed Hurt, Jesús de la Cruz, and Brigitte Pertschy
E-Jahr:2022
Jahr:19 Apr 2022
Umfang:15 S.
Fussnoten:Gesehen am 04.08.2022
Titel Quelle:Enthalten in: RNA biology
Ort Quelle:Philadelphia, Pa. : Taylor & Francis, 2004
Jahr Quelle:2022
Band/Heft Quelle:19(2022), 1, Seite 560-574
ISSN Quelle:1555-8584
Abstract:The small ribosomal subunit protein Rps15/uS19 is involved in early nucleolar ribosome biogenesis and subsequent nuclear export of pre-40S particles to the cytoplasm. In addition, the C-terminal tail of Rps15 was suggested to play a role in mature ribosomes, namely during translation elongation. Here, we show that Rps15 not only functions in nucleolar ribosome assembly but also in cytoplasmic pre-40S maturation, which is indicated by a strong genetic interaction between Rps15 and the 40S assembly factor Ltv1. Specifically, mutations either in the globular or C-terminal domain of Rps15 when combined with the non-essential ltv1 null allele are lethal or display a strong growth defect. However, not only rps15 ltv1 double mutants but also single rps15 C-terminal deletion mutants exhibit an accumulation of the 20S pre-rRNA in the cytoplasm, indicative of a cytoplasmic pre-40S maturation defect. Since in pre-40S particles, the C-terminal tail of Rps15 is positioned between assembly factors Rio2 and Tsr1, we further tested whether Tsr1 is genetically linked to Rps15, which indeed could be demonstrated. Thus, the integrity of the Rps15 C-terminal tail plays an important role during late pre-40S maturation, perhaps in a quality control step to ensure that only 40S ribosomal subunits with functional Rps15 C-terminal tail can efficiently enter translation. As mutations in the C-terminal tail of human RPS15 have been observed in connection with chronic lymphocytic leukaemia, it is possible that apart from defects in translation, an impaired late pre-40S maturation step in the cytoplasm could also be a reason for this disease.
DOI:doi:10.1080/15476286.2022.2064073
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1080/15476286.2022.2064073
 DOI: https://doi.org/10.1080/15476286.2022.2064073
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:40S ribosomal subunit
 chronic lymphocytic leukaemia
 CLL
 ribosomal protein
 Ribosome biogenesis
 rps15/uS19
 yeast
K10plus-PPN:1813231427
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68950297   QR-Code
zum Seitenanfang