Maternal iron status in early pregnancy and DNA methylation in offspring

• Verfasst von: Täubert, Minerva Jazmin [VerfasserIn]
• Verfasst von: de Prado-Bert, P. [VerfasserIn]
• Verfasst von: Geurtsen, M. L. [VerfasserIn]
• Verfasst von: Mancano, G. [VerfasserIn]
• Verfasst von: Vermeulen, M. J. [VerfasserIn]
• Verfasst von: Reiss, I. K. M. [VerfasserIn]
• Verfasst von: Caramaschi, D. [VerfasserIn]
• Verfasst von: Sunyer, J. [VerfasserIn]
• Verfasst von: Sharp, G. C. [VerfasserIn]
• Verfasst von: Julvez, J. [VerfasserIn]
• Verfasst von: Muckenthaler, Martina [VerfasserIn]
• Verfasst von: Felix, J. F. [VerfasserIn]
• Titel: Maternal iron status in early pregnancy and DNA methylation in offspring
• Titelzusatz: an epigenome-wide meta-analysis
• Verf.angabe: M.J. Taeubert, P. de Prado-Bert, M.L. Geurtsen, G. Mancano, M.J. Vermeulen, I.K.M. Reiss, D. Caramaschi, J. Sunyer, G.C. Sharp, J. Julvez, M.U. Muckenthaler and J.F. Felix
• E-Jahr: 2022
• Jahr: 03 May 2022
• Umfang: 12 S.
• Fussnoten: Gesehen am 05.08.2022
• Titel Quelle: Enthalten in: Clinical epigenetics
• Ort Quelle: [S.l.] : BioMed Central, 2010
• Jahr Quelle: 2022
• Band/Heft Quelle: 14(2022), 1, Artikel-ID 59, Seite 1-12
• ISSN Quelle: 1868-7083
• DOI: doi:10.1186/s13148-022-01276-w
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Differentially methylated regions
• Sach-SW: DNA methylation
• Sach-SW: Epigenetics
• Sach-SW: Iron metabolism
• Sach-SW: Maternal serum ferritin
• K10plus-PPN: 1813360251

Abstract

Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking environmental exposures such as micronutrient status during pregnancy with offspring health. We performed a meta-analysis on the association of maternal early-pregnancy serum ferritin concentrations, as a marker of body iron stores, and cord blood DNA methylation. We included 1286 mother-newborn pairs from two population-based prospective cohorts. Serum ferritin concentrations were measured in early pregnancy. DNA methylation was measured with the Infinium HumanMethylation450 BeadChip (Illumina). We examined epigenome-wide associations of maternal early-pregnancy serum ferritin and cord blood DNA methylation using robust linear regression analyses, with adjustment for confounders and performed fixed-effects meta-analyses. We additionally examined whether associations of any CpGs identified in cord blood persisted in the peripheral blood of older children and explored associations with other markers of maternal iron status. We also examined whether similar findings were present in the association of cord blood serum ferritin concentrations with cord blood DNA methylation.