| |  Online-Ressource |
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| Verfasst von: | Meissburger, Bettina [VerfasserIn]  |
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| | Ukropec, Jozef [VerfasserIn] |
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| | Roeder, Eva [VerfasserIn] |
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| | Beaton, Nigel [VerfasserIn] |
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| | Geiger, Matthias [VerfasserIn] |
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| | Teupser, Daniel [VerfasserIn] |
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| | Civan, Burcak [VerfasserIn] |
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| | Langhans, Wolfgang [VerfasserIn] |
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| | Nawroth, Peter Paul [VerfasserIn] |
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| | Gasperikova, Daniela [VerfasserIn] |
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| | Rudofsky, Gottfried [VerfasserIn] |
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| | Wolfrum, Christian [VerfasserIn] |
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| Titel: | Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma |
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| Verf.angabe: | Bettina Meissburger, Jozef Ukropec, Eva Roeder, Nigel Beaton, Matthias Geiger, Daniel Teupser, Burcak Civan, Wolfgang Langhans, Peter P. Nawroth, Daniela Gasperikova, Gottfried Rudofsky, Christian Wolfrum |
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| E-Jahr: | 2011 |
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| Jahr: | 19 August 2011 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 17.08.2022 |
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| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationEMBO molecular medicine |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2009 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 3(2011), 11, Seite 637-651 |
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| ISSN Quelle: | 1757-4684 |
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| Abstract: | Abstract Obesity is a well-known risk factor for the development of secondary complications such as type 2 diabetes. However, only a part of the obese population develops secondary metabolic disorders. Here, we identify the transcription factor retinoid-related orphan receptor gamma (ROR?) as a negative regulator of adipocyte differentiation through expression of its newly identified target gene matrix metalloproteinase 3. In vivo differentiation of adipocyte progenitor cells from Ror?-deficient mice is enhanced and obese Ror??/? mice show decreased adipocyte sizes. These small adipocytes are highly insulin sensitive, leading to an improved control of circulating free fatty acids. Ultimately, Ror??/? mice are protected from hyperglycemia and insulin resistance in the state of obesity. In adipose stromal-vascular fraction from obese human subjects, Ror? expression is correlated with adipocyte size and negatively correlated with adipogenesis and insulin sensitivity. Taken together, our findings identify ROR? as a factor, which controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. ROR? might therefore serve as a novel pharmaceutical target to treat obesity-associated insulin resistance. |
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| DOI: | doi:10.1002/emmm.201100172 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/emmm.201100172 |
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| | Volltext: https://www.embopress.org/doi/full/10.1002/emmm.201100172 |
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| | DOI: https://doi.org/10.1002/emmm.201100172 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adipogenesis |
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| | matrix metalloproteinase 3 |
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| | obesity |
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| | retinoid-related orphan receptor gamma |
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| | type 2 diabetes |
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| K10plus-PPN: | 1814531610 |
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| Verknüpfungen: | → Zeitschrift |
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Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma / Meissburger, Bettina [VerfasserIn]; 19 August 2011 (Online-Ressource)
