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Status: Bibliographieeintrag

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Verfasst von:Bebon, Rick [VerfasserIn]   i
 Schwarz, Ulrich S. [VerfasserIn]   i
Titel:First-passage times in complex energy landscapes
Titelzusatz:a case study with nonmuscle myosin II assembly
Verf.angabe:Rick Bebon and Ulrich S Schwarz
E-Jahr:2022
Jahr:30 June 2022
Umfang:16 S.
Fussnoten:Gesehen am 17.08.2022
Titel Quelle:Enthalten in: New journal of physics
Ort Quelle:[Bad Honnef] : Dt. Physikalische Ges., 1999
Jahr Quelle:2022
Band/Heft Quelle:24(2022), 6 vom: Juni, Artikel-ID 063034, Seite 1-16
ISSN Quelle:1367-2630
Abstract:Complex energy landscapes often arise in biological systems, e.g. for protein folding, biochemical reactions, or intracellular transport processes. Their physical effects are frequently reflected in the first-passage times (FPTs) arising from these energy landscapes. However, their calculation is notoriously challenging and it is often difficult to identify the most relevant features of a given energy landscape. Here we show how this can be achieved by coarse-graining the Fokker-Planck equation to a master equation and decomposing its FPTs in an iterative process. We apply this method to the electrostatic interaction between two rods of nonmuscle myosin II (NM2), which is the main molecular motor for force generation in nonmuscle cells. Energy landscapes are computed directly from the amino acid sequences of the three different isoforms. Our approach allows us to identify the most relevant energy barriers for their self-assembly into NM2 minifilaments and how they change under force. In particular, we find that antiparallel configurations are more stable than parallel ones, but also show more changes under mechanical loading. Our work demonstrates the rich dynamics that can be expected for NM2-assemblies under mechanical load and in general shows how one can identify the most relevant energy barriers in complex energy landscapes.
DOI:doi:10.1088/1367-2630/ac78fd
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1088/1367-2630/ac78fd
 DOI: https://doi.org/10.1088/1367-2630/ac78fd
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1814578242
Verknüpfungen:→ Zeitschrift

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