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Verfasst von:Mercker, Moritz [VerfasserIn]   i
 Richter, Thomas [VerfasserIn]   i
 Hartmann, Dirk [VerfasserIn]   i
Titel:Sorting mechanisms and communication in phase-separating coupled monolayers
Verf.angabe:Moritz Mercker, Thomas Richter, and Dirk Hartmann
E-Jahr:2011
Jahr:22 September 2011
Umfang:7 S.
Fussnoten:Gesehen am 18.08.2022
Titel Quelle:Enthalten in: The journal of physical chemistry <Washington, DC> / B
Ort Quelle:Washington, DC : Soc., 1997
Jahr Quelle:2011
Band/Heft Quelle:115(2011), 40, Seite 11739-11745
ISSN Quelle:1520-5207
Abstract:A continuous model of two coupled monolayers constituting a fluid bilayer membrane is presented. The model is based on the minimization of a membrane free energy considering in both monolayer leaflets two different molecule types, undergoing lateral phase separation. Differences in the mechanical properties of the molecules, such as shape, stiffness, and length are accounted explicitly by the model. In the presented model, coupling between monolayers is realized via an energy-based model depending on the local distance between the two monolayers as well as the lengths of molecules constituting the local monolayer region. We numerically study different passive mechanisms for molecule sorting and correlation across the bilayer induced by first-order mechanical constraints. Here, we focus on three aspects: First, we find that stretching of the two monolayers in the normal direction yields a sorting of molecules according to their length. Furthermore, we show that the length of molecules can be used to synchronize phases across the bilayer membrane. Moreover, we find that generating curvature in one layer (induced by different curvature creating mechanisms) sorts molecules of the other layer according to their shape and stiffness. Many recent experimental data indicate the importance of specific lipid–protein interactions and the role of the bilayer thickness in membrane protein function and sorting. The presented model proposes different mechanisms leading to a colocalization of different components in different monolayers at the same place at the same time.
DOI:doi:10.1021/jp204127g
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: http://dx.doi.org/10.1021/jp204127g
 DOI: https://doi.org/10.1021/jp204127g
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1008756849
Verknüpfungen:→ Zeitschrift

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