| Online-Ressource |
Verfasst von: | Klein, Ulrike [VerfasserIn]  |
| Jauch, Anna [VerfasserIn]  |
| Hielscher, Thomas [VerfasserIn]  |
| Hillengaß, Jens [VerfasserIn]  |
| Raab, Marc-Steffen [VerfasserIn]  |
| Seckinger, Anja [VerfasserIn]  |
| Hose, Dirk [VerfasserIn]  |
| Ho, Anthony Dick [VerfasserIn]  |
| Goldschmidt, Hartmut [VerfasserIn]  |
| Neben, Kai [VerfasserIn]  |
Titel: | Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone |
Verf.angabe: | Ulrike Klein, Anna Jauch, Thomas Hielscher, Jens Hillengass, Marc S. Raab, Anja Seckinger, Dirk Hose, Anthony D. Ho, Hartmut Goldschmidt, and Kai Neben |
Jahr: | 2011 |
Umfang: | 9 S. |
Fussnoten: | Published online December 3, 2010 ; Gesehen am 18.08.2022 |
Titel Quelle: | Enthalten in: Cancer |
Ort Quelle: | New York, NY : Wiley-Liss, 1948 |
Jahr Quelle: | 2011 |
Band/Heft Quelle: | 117(2011), 10, Seite 2136-2144 |
ISSN Quelle: | 1097-0142 |
Abstract: | Background: In the era of novel agents such as lenalidomide and bortezomib, risk stratification by chromosomal abnormalities may enable a more rational selection of therapeutic approaches in patients with multiple myeloma (MM). Methods: The authors analyzed the prognostic value of deletion del(13q14), del(17p13), +1q21, translocation t(4;14), t(11;14), and t(14;16) by fluorescence in situ hybridization (FISH) in a series of 92 patients with recurrent MM who were treated with lenalidomide and dexamethasone (len/dex) at the study center. Results: Patients carrying del(13q14) or t(14;16) were found to have a shorter median time to disease progression (TTP) of 5.1 months (vs 14.4 months; P = .009) and 2.0 months (vs 10.5 months; P <.001), respectively. However, no effect on TTP was observed in patients harboring del(13q14) as an exclusive chromosomal aberration without the concomitant presence of t(4;14) or del(17p13). The median overall survival (OS) for patients with del(17p13) or +1q21 was 6.7 months (P = .002) and 8.3 months (P < .001), respectively, whereas the median OS for patients carrying none of these abnormalities was not reached. Multivariate analysis revealed that the effects of del(17p13) and +1q21 on OS were independent of patient age as well as the type and number of regimens administered before len/dex. Conclusions: The results of the current study suggest that the prognostic significance of t(4;14) may be ameliorated or eliminated in patients treated with len/dex, whereas the presence of del(17p13) or +1q21 is still associated with a dismal OS. The presence of t(11;14) and del(13q14) as exclusive chromosomal aberrations indicates no impact on outcome. Because of its rarity in MM, a confirmation of the prognostic role of the t(14;16) aberration is still pending. |
DOI: | doi:10.1002/cncr.25775 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/cncr.25775 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.25775 |
| DOI: https://doi.org/10.1002/cncr.25775 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | cytogenetics |
| lenalidomide |
| multiple myeloma |
| overall survival |
K10plus-PPN: | 1814688935 |
Verknüpfungen: | → Zeitschrift |
Chromosomal aberrations +1q21 and del(17p13) predict survival in patients with recurrent multiple myeloma treated with lenalidomide and dexamethasone / Klein, Ulrike [VerfasserIn]; 2011 (Online-Ressource)