| |  Online-Ressource |
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| Verfasst von: | Jäckle, Katharina [VerfasserIn]  |
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| | Lippross, Sebastian [VerfasserIn] |
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| | Michel, Theresa Elisabeth [VerfasserIn] |
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| | Kowallick, Johannes T. [VerfasserIn] |
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| | Dullin, Christian [VerfasserIn] |
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| | Lüders, Katja A. [VerfasserIn] |
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| | Lorenz, Heiko M. [VerfasserIn] |
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| | Tsaknakis, Konstantinos [VerfasserIn] |
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| | Hell, Anna K. [VerfasserIn] |
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| Titel: | A preclinical pilot study on the effects of thermal ablation on lamb growth plates |
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| Verf.angabe: | Katharina Jäckle, Sebastian Lippross, Theresa Elisabeth Michel, Johannes T. Kowallick, Christian Dullin, Katja A. Lüders, Heiko M. Lorenz, Konstantinos Tsaknakis and Anna K. Hell |
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| E-Jahr: | 2022 |
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| Jahr: | 12 June 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 18.08.2022 |
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| Titel Quelle: | Enthalten in: Children |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 9(2022), 6, Artikel-ID 878, Seite 1-10 |
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| ISSN Quelle: | 2227-9067 |
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| Abstract: | (1) Background: Thermal ablation has been demonstrated to affect the bone growth of osteoid osteoma in adolescents. Growth modulation due to thermal heat in children is conceivable, but has not yet been established. We used lamb extremities as a preclinical model to examine the effect of thermal ablation on growth plates in order to evaluate its potential for axial or longitudinal growth modulation in pediatric patients. (2) Methods: Thermal ablation was performed by electrocautery on eight different growth plates of the legs and distal radii of a stillborn lamb. After treatment, target hits and the physical extent of the growth plate lesions were monitored using micro-computed tomography (micro-CT) and histology. (3) Results: Lesions and their physical extent could be quantified in 75% of the treated extremities. The histological analysis revealed that the disruption of tissue was confined to a small area and the applied heat did not cause the entire growth plate to be disrupted or obviously damaged. (4) Conclusions: Thermal ablation by electrocautery is minimally invasive and can be used for targeted disruption of small areas in growth plates in the animal model. The results suggest that thermal ablation can be developed into a suitable method to influence epiphyseal growth in children. |
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| DOI: | doi:10.3390/children9060878 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/children9060878 |
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| | Volltext: https://www.mdpi.com/2227-9067/9/6/878 |
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| | DOI: https://doi.org/10.3390/children9060878 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | accuracy |
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| | growth modulation |
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| | growth plate |
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| | histology |
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| | linseed sheep |
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| | thermal ablation |
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| K10plus-PPN: | 1814704981 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ preclinical pilot study on the effects of thermal ablation on lamb growth plates / Jäckle, Katharina [VerfasserIn]; 12 June 2022 (Online-Ressource)
