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| Verfasst von: | Oliver Metzig, Marie [VerfasserIn]  |
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| | Nickles, Dorothee [VerfasserIn] |
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| | Falschlehner, Christina [VerfasserIn] |
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| | Lehmann-Koch, Judith [VerfasserIn] |
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| | Straub, Beate Katharina [VerfasserIn] |
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| | Roth, Wilfried [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| Titel: | An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling |
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| Verf.angabe: | Marie Metzig, Dorothee Nickles, Christina Falschlehner, Judith Lehmann-Koch, Beate K. Straub, Wilfried Roth and Michael Boutros |
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| E-Jahr: | 2011 |
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| Jahr: | 07 April 2011 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 19.08.2022 |
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| Titel Quelle: | Enthalten in: International journal of cancer |
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| Ort Quelle: | Bognor Regis : Wiley-Liss, 1966 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 129(2011), 3, Seite 607-618 |
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| ISSN Quelle: | 1097-0215 |
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| Abstract: | Tumor necrosis factor α (TNF-α) signaling pathways play important roles during tumorigenesis and inflammation. Ubiquitin-dependent processes are central to the regulation of TNF-α and nuclear factor κB (NF-κB) signaling. We performed a targeted siRNA screen for ubiquitin-specific proteases (USPs) and identified USP2 as a modulator of TNF-α-induced NF-κB signaling. We showed that USP2 is required for the phosphorylation of IκB, nuclear translocation of NF-κB and expression of NF-κB-dependent target genes and IL-8 secretion. Our study also provides evidence for isoform-specific functions of USP2. The immunohistochemical analysis of breast carcinomas revealed that USP2 expression is frequently downregulated. Together, our results implicate USP2 as a novel positive regulator of TNF-α-induced NF-κB signaling and show that its expression is altered in tumor cells. |
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| DOI: | doi:10.1002/ijc.26124 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/ijc.26124 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.26124 |
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| | DOI: https://doi.org/10.1002/ijc.26124 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: An RNAi screen identifies USP2 as a factor required for TNF-alpha-induced NF-kappaB signaling. - 2011 |
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| Sach-SW: | breast cancer |
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| | functional genomics |
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| | NF-κB |
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| | RNAi |
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| | signaling |
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| K10plus-PPN: | 1814722467 |
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| Verknüpfungen: | → Zeitschrift |
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¬An¬ RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling / Oliver Metzig, Marie [VerfasserIn]; 07 April 2011 (Online-Ressource)
