Concurrent change in serum cholinesterase activity and midregional-proadrennomedullin level could predict patient outcome following liver transplantation

• Verfasst von: Decker, Sebastian [VerfasserIn]
• Verfasst von: Krüger, Albert [VerfasserIn]
• Verfasst von: Wilk, Henryk [VerfasserIn]
• Verfasst von: Uhle, Florian [VerfasserIn]
• Verfasst von: Bruckner, Thomas [VerfasserIn]
• Verfasst von: Hofer, Stefan [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Verfasst von: Brenner, Thorsten [VerfasserIn]
• Verfasst von: Živković, Aleksandar [VerfasserIn]
• Titel: Concurrent change in serum cholinesterase activity and midregional-proadrennomedullin level could predict patient outcome following liver transplantation
• Verf.angabe: Sebastian O. Decker, Albert Krüger, Henryk Wilk, Florian Uhle, Thomas Bruckner, Stefan Hofer, Markus A. Weigand, Thorsten Brenner and Aleksandar R. Zivkovic
• E-Jahr: 2022
• Jahr: 15 July 2022
• Umfang: 17 S.
• Fussnoten: Gesehen am 19.08.2022
• Titel Quelle: Enthalten in: Biomolecules
• Ort Quelle: Basel : MDPI, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), 7, Artikel-ID 989, Seite 1-17
• ISSN Quelle: 2218-273X
• DOI: doi:10.3390/biom12070989
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: liver transplantation
• Sach-SW: mid-regional proadrenomedullin
• Sach-SW: outcome
• Sach-SW: pseudocholinesterase
• K10plus-PPN: 1814722785
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Background: After liver transplantation (LTX), patients are susceptible to opportunistic infections resulting in reduced outcomes within the early post-transplantation period. The postoperative monitoring of LTX patients has gained much importance in recent years. However, reliable plasmatic markers predicting 90-day outcomes are still lacking. Methods: In the post hoc analysis of a prospective, observational study, butyrylcholinesterase (BChE), mid-regional proadrenomedullin (MR-proADM), as well as conventional inflammatory markers (procalcitonin, C-reactive protein) were evaluated in 93 patients at seven consecutive timepoints within the first 28 days following LTX. Results: Persistently reduced activity of BChE and elevated MR-proADM levels indicated reduced 90-day survival following LTX. Furthermore, reduced BChE and increased MR-proADM activity could indicate early post-transplantation bacterial infections, whereas conventional inflammatory biomarkers showed no diagnostic efficacy within the observation period. Conclusion: Concurrent assessment of BChE and MR-proADM activity might serve as a bedside diagnostic tool for early bacterial infections following liver transplantation. Thus, a combined utilization of the two biomarkers may be a useful tool in the risk evaluation of patients following liver transplantation.