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Verfasst von:Kronlage, Moritz [VerfasserIn]   i
 Fischer, Thomas David [VerfasserIn]   i
 Behnisch, Rouven [VerfasserIn]   i
 Schwarz, Daniel [VerfasserIn]   i
 Bäumer, Philipp [VerfasserIn]   i
 Münch, Véronique [VerfasserIn]   i
 Heiland, Sabine [VerfasserIn]   i
 Bendszus, Martin [VerfasserIn]   i
 Godel, Tim [VerfasserIn]   i
Titel:Dorsal root ganglia volume
Titelzusatz:normative values, correlation with demographic determinants and reliability of three different methods of volumetry
Verf.angabe:Moritz Kronlage, Thomas David Fischer, Rouven Behnisch, Daniel Schwarz, Philipp Bäumer, Veronique Schwehr, Sabine Heiland, Martin Bendszus and Tim Godel
E-Jahr:2022
Jahr:28 June 2022
Umfang:14 S.
Fussnoten:Gesehen am 19.08.2022
Titel Quelle:Enthalten in: Diagnostics
Ort Quelle:Basel : MDPI, 2011
Jahr Quelle:2022
Band/Heft Quelle:12(2022), 7, Artikel-ID 1570, Seite 1-14
ISSN Quelle:2075-4418
Abstract:Background: Dorsal root ganglia (DRG) volume assessment by MR-Neurography (MRN) has evolved to an important imaging marker in the diagnostic workup of various peripheral neuropathies and pain syndromes. The aim of this study was (1) to assess normal values of DRG volume and correlations with demographic determinants and (2) to quantify the inter-reader and inter-method reliability of three different methods of DRG volumetry. Methods: Sixty healthy subjects (mean age: 59.1, range 23-79) were examined using a 3D T2-weighted MRN of the lumbosacral plexus at 3 Tesla. Normal values of DRG L3 to S2 were obtained after exact volumetry based on manual 3D segmentation and correlations with demographic variables were assessed. For the assessment of inter-reader and inter-method reliability, DRG volumes in a subset of 25 participants were measured by two independent readers, each applying (1) exact volumetry based on 3D segmentation, (2) axis-corrected, and (3) non-axis-corrected volume estimation. Intraclass correlation coefficients were reported and the Bland-Altman analysis was conducted. Results: Mean DRG volumes ranged from 124.8 mm3 for L3 to 323.3 mm3 for S1 and did not differ between right and left DRG. DRG volume (mean of L3 to S1) correlated with body height (r = 0.42; p = 0.0008) and weight (r = 0.34; p = 0.0087). DRG of men were larger than of women (p = 0.0002); however, no difference remained after correction for body height. Inter-reader reliability was high for all three methods but best for exact volumetry (ICC = 0.99). While axis-corrected estimation was not associated with a relevant bias, non-axis-corrected estimation systematically overestimated DRG volume by on average of 15.55 mm3 (reader 1) or 18.00 mm3 (reader 2) when compared with exact volumetry. Conclusion: The here presented normal values of lumbosacral DRG volume and the correlations with height and weight may be considered in future disease specific studies and possible clinical applications. Exact volumetry was most reliable and should be considered the gold standard. However, the reliability of axis-corrected and non-axis-corrected volume estimation was also high and might still be sufficient, depending on the degree of the required measurement accuracy.
DOI:doi:10.3390/diagnostics12071570
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext: https://doi.org/10.3390/diagnostics12071570
 kostenfrei: Volltext: https://www.mdpi.com/2075-4418/12/7/1570
 DOI: https://doi.org/10.3390/diagnostics12071570
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:demographic determinants
 dorsal root ganglia
 imaging marker
 magnetic resonance neurography
K10plus-PPN:1814723439
Verknüpfungen:→ Zeitschrift

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