| |  Online-Ressource |
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| Verfasst von: | Sobol, Benjamin [VerfasserIn]  |
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| | Azzam Nieto, Osama [VerfasserIn] |
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| | Eberlein, Emily Lara [VerfasserIn] |
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| | Scherr, Anna-Lena [VerfasserIn] |
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| | Ismail, Lars [VerfasserIn] |
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| | Keßler, Annika [VerfasserIn] |
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| | Nader, Luisa [VerfasserIn] |
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| | Schwab, Maximilian [VerfasserIn] |
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| | Hoffmeister-Wittmann, Paula [VerfasserIn] |
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| | Schmitt, Nathalie [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Welte, Stefan Ezechiel [VerfasserIn] |
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| | Seidensaal, Katharina [VerfasserIn] |
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| | Christopoulos, Petros [VerfasserIn] |
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| | Heilig, Christoph E. [VerfasserIn] |
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| | Kriegsmann, Katharina [VerfasserIn] |
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| | Fröhling, Stefan [VerfasserIn] |
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| | Kriegsmann, Mark [VerfasserIn] |
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| | Heß, Jochen [VerfasserIn] |
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| | Köhler, Bruno Christian [VerfasserIn] |
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| Titel: | Specific targeting of antiapoptotic Bcl-2 proteins as a radiosensitizing approach in solid tumors |
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| Verf.angabe: | Benjamin Sobol, Osama Azzam Nieto, Emily Lara Eberlein, Anna-Lena Scherr, Lars Ismail, Annika Kessler, Luisa Nader, Maximilian Schwab, Paula Hoffmeister, Nathalie Schmitt, Dirk Jäger, Stefan Welte, Katharina Seidensaal, Petros Christopoulos, Christoph Heilig, Katharina Kriegsmann, Stefan Fröhling, Mark Kriegsmann, Jochen Hess and Bruno Christian Köhler |
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| E-Jahr: | 2022 |
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| Jahr: | 16 July 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 19.08.2022 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 23(2022), 14, Artikel-ID 7850, Seite 1-13 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Avoidance of therapy-induced apoptosis is a hallmark of acquired resistance towards radiotherapy. Thus, breaking resistance still challenges modern cancer therapy. The Bcl-2 protein family is known for its regulatory role in apoptosis signaling, making Bcl-2, Mcl-1 and Bcl-xL promising targets. This study evaluates the effects of highly specific inhibitors for Bcl-xL (WEHI-539), Bcl-2 (ABT-199) and Mcl-1 (S63845) as radiosensitizers. Covering a broad spectrum of solid tumors, Non-Small-Cell Lung Cancer (NSCLC), Head and Neck Squamous Cell Carcinoma (HNSCC) and synovial sarcoma cell lines were exposed to fractionated radiation as standard therapy with or without Bcl-2 protein inhibition. Protein expression was detected by Western blot and cell death was assessed by flow cytometry measuring apoptosis. In contrast to NSCLC, a high level of Bcl-xL and its upregulation during radiotherapy indicated radioresistance in HNSCC and synovial sarcoma. Radioresistant cell lines across all entities benefited synergistically from combined therapy with Bcl-xL inhibition and fractionated radiation. In NSCLC cell lines, Mcl-1 inhibition significantly augmented radiotherapy independent of the expression level. Our data suggest that among antiapoptotic Bcl-2 proteins, targeting Bcl-xL may break resistance to radiation in HNSCC, synovial sarcoma and NSCLC in vitro. In NSCLC, Mcl-1 might be a promising target that needs further investigation. |
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| DOI: | doi:10.3390/ijms23147850 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms23147850 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/23/14/7850 |
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| | DOI: https://doi.org/10.3390/ijms23147850 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Bcl-2 |
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| | Bcl-x<sub>L</sub> |
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| | cell death |
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| | head and neck squamous cell carcinoma |
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| | Mc-1 |
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| | non-small-cell lung cancer |
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| | radiotherapy |
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| | synovial sarcoma |
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| | therapy resistance |
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| K10plus-PPN: | 1814740139 |
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| Verknüpfungen: | → Zeitschrift |
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Specific targeting of antiapoptotic Bcl-2 proteins as a radiosensitizing approach in solid tumors / Sobol, Benjamin [VerfasserIn]; 16 July 2022 (Online-Ressource)
