Comparison of optic disc ovality index and rotation angle measurements in myopic eyes using photography and OCT based techniques

• Verfasst von: Rezapour, Jasmin [VerfasserIn]
• Verfasst von: Tran, Andrew Q. [VerfasserIn]
• Verfasst von: Bowd, Christopher [VerfasserIn]
• Verfasst von: El-Nimri, Nevin W. [VerfasserIn]
• Verfasst von: Belghith, Akram [VerfasserIn]
• Verfasst von: Christopher, Mark [VerfasserIn]
• Verfasst von: Brye, Nicole [VerfasserIn]
• Verfasst von: Proudfoot, James A. [VerfasserIn]
• Verfasst von: Dohleman, Jade [VerfasserIn]
• Verfasst von: Fazio, Massimo A. [VerfasserIn]
• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Verfasst von: Weinreb, Robert N. [VerfasserIn]
• Verfasst von: Zangwill, Linda M. [VerfasserIn]
• Titel: Comparison of optic disc ovality index and rotation angle measurements in myopic eyes using photography and OCT based techniques
• Verf.angabe: Jasmin Rezapour, Andrew Q. Tran, Christopher Bowd, Nevin W. El-Nimri, Akram Belghith, Mark Christopher, Nicole Brye, James A. Proudfoot, Jade Dohleman, Massimo A. Fazio, Jost B. Jonas, Robert N. Weinreb and Linda M. Zangwill
• E-Jahr: 2022
• Jahr: 24 June 2022
• Umfang: 11 S.
• Fussnoten: Gesehen am 23.08.2022
• Titel Quelle: Enthalten in: Frontiers in medicine
• Ort Quelle: Lausanne : Frontiers Media, 2014
• Jahr Quelle: 2022
• Band/Heft Quelle: 9(2022), Artikel-ID 872658, Seite 1-11
• ISSN Quelle: 2296-858X
• DOI: doi:10.3389/fmed.2022.872658
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: axial myopia
• Sach-SW: Bruch's membrane opening
• Sach-SW: clinical disc margin
• Sach-SW: glaucoma
• Sach-SW: high myopia
• Sach-SW: OCT
• Sach-SW: OCT landmarks
• Sach-SW: optic nerve head morphology
• K10plus-PPN: 181500665X

Abstract

Purpose: To compare optic nerve head (ONH) ovality index and rotation angle measurements based on semi-automated delineation of the clinical ONH margin derived from photographs and automated BMO configuration derived from optical coherence tomography (OCT) images in healthy and glaucomatous eyes with high-, mild- and no axial myopia. - Methods: One hundred seventy-five healthy and glaucomatous eyes of 146 study participants enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS) with optic disc photographs and Spectralis OCT ONH scans acquired on the same day were stratified by level of axial myopia (non-myopic [n = 56, axial length (AL) <24 mm], mild-myopic [n = 58, AL 24-26 mm] and high-myopic [n = 32, AL >26 mm]. The clinical disc margin of each photograph was manually annotated, and semi-automated measurements were recorded of the ovality index and rotation angle based on a best-fit ellipse generated using ImageJ software. These semi-automated photograph-based measurements were compared to ovality index and rotation angle generated from custom automated BMO-based analysis using segmented OCT ONH volumes. R 2 values from linear mixed effects models were used to describe the associations between semi-automated, photograph-based and automated OCT-based measurements. - Results: Average (95% CI) axial length was 23.3 (23.0, 23.3) mm, 24.8 (24.7, 25.0) mm and 26.8 (26.6, 27.0) mm in non-myopic, mild-myopic and high-myopic eyes, respectively (ANOVA, p ≤ 0.001 for all). The R 2 association (95% CI) between semi-automated photograph-based and automated OCT-based assessment of ONH OI for all eyes was [0.26 (0.16, 0.36); p < 0.001]. This association was weakest in non-myopic eyes [0.09 (0.01, 0.26); p = 0.02], followed by mild-myopic eyes [0.13 (0.02, 0.29); p = 0.004] and strongest in high-myopic eyes [0.40 (0.19, 0.60); p < 0.001]. No significant associations were found between photography- and OCT-based assessment of rotation angle with R 2 values ranging from 0.00 (0.00, 0.08) in non-myopic eyes to 0.03 (0.00, 0.21) in high-myopic eyes (all associations p ≥ 0.33). - Conclusions: Agreement between photograph-based and automated OCT-based ONH morphology measurements is limited, suggesting that these methods cannot be used interchangeably for characterizing myopic changes in the ONH.