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| Verfasst von: | Sirinian, Chaido [VerfasserIn]  |
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| | Peroukidis, Stavros [VerfasserIn] |
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| | Kriegsmann, Katharina [VerfasserIn] |
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| | Chaniotis, Dimitrios [VerfasserIn] |
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| | Koutras, Angelos [VerfasserIn] |
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| | Kriegsmann, Mark [VerfasserIn] |
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| | Papanastasiou, Anastasios D. [VerfasserIn] |
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| Titel: | Cellular senescence in normal mammary gland and breast cancer |
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| Titelzusatz: | implications for cancer therapy |
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| Verf.angabe: | Chaido Sirinian, Stavros Peroukidis, Katharina Kriegsmann, Dimitrios Chaniotis, Angelos Koutras, Mark Kriegsmann and Anastasios D. Papanastasiou |
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| E-Jahr: | 2022 |
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| Jahr: | 1 June 2022 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 24.08.2022 ; This article belongs to the special issue "Molecular therapeutics of breast cancer" |
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| Titel Quelle: | Enthalten in: Genes |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022), 6, special issue, Artikel-ID 994, Seite 1-10 |
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| ISSN Quelle: | 2073-4425 |
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| Abstract: | Cellular senescence (CS) is a major homeostatic biological process, which plays a key role in normal tissue development and provides protection from stressful cell insults. The role of CS in mammary-gland development and breast cancer is not well understood. While there is a lack of experimental data on the role of CS in the development of the pre-pubertal mammary gland, there is evidence for a biphasic senescence response in adult normal-mammary-epithelial cells, where the bypass of the first senescence barrier (M0) seems to be a key step in the development of premalignant lesions, with genetic abnormalities that resemble in situ breast carcinoma. Further, there is accumulating evidence for the role of cellular senescence in breast-cancer response, regarding treatment and patient outcome. Here, we review the current literature on cellular senescence, in epithelial-mammary cells, breast-cancer cells, and breast-tumor-microenvironment-resident cells. Furthermore, we discuss its putative role in breast-cancer response, regarding treatment and disease progression. In addition, we provide preliminary evidence of CS in breast-cancer-microenvironment cells, such as tumor-associated fibroblasts and tumor-infiltrating lymphocytes, by employing the novel GL13 lipofuscin stain, as a marker of cellular senescence. |
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| DOI: | doi:10.3390/genes13060994 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/genes13060994 |
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| | Volltext: https://www.mdpi.com/2073-4425/13/6/994 |
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| | DOI: https://doi.org/10.3390/genes13060994 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | breast cancer |
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| | cellular senescence |
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| | chemotherapy |
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| | GL13 |
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| | IHC |
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| | mammary gland |
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| K10plus-PPN: | 1815085649 |
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| Verknüpfungen: | → Zeitschrift |
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Cellular senescence in normal mammary gland and breast cancer / Sirinian, Chaido [VerfasserIn]; 1 June 2022 (Online-Ressource)
