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| Verfasst von: | Fresnais, Margaux [VerfasserIn]  |
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| | Liang, Siwen [VerfasserIn] |
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| | Breitkopf, Marius [VerfasserIn] |
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| | Lindner, Joshua Raoul [VerfasserIn] |
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| | Claude, Emmanuelle [VerfasserIn] |
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| | Pringle, Steven [VerfasserIn] |
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| | Levkin, Pavel [VerfasserIn] |
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| | Demir, Konstantin [VerfasserIn] |
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| | Benzel, Julia [VerfasserIn] |
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| | Sundheimer, Julia [VerfasserIn] |
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| | Statz, Britta [VerfasserIn] |
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| | Pajtler, Kristian Wilfried [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Haefeli, Walter E. [VerfasserIn] |
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| | Burhenne, Jürgen [VerfasserIn] |
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| | Longuespée, Rémi [VerfasserIn] |
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| Titel: | Analytical performance evaluation of new DESI enhancements for targeted drug quantification in tissue sections |
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| Verf.angabe: | Margaux Fresnais, Siwen Liang, Marius Breitkopf, Joshua Raoul Lindner, Emmanuelle Claude, Steven Pringle, Pavel A. Levkin, Konstantin Demir, Julia Benzel, Julia Sundheimer, Britta Statz, Kristian W. Pajtler, Stefan M. Pfister, Walter E. Haefeli, Jürgen Burhenne and Rémi Longuespée |
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| E-Jahr: | 2022 |
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| Jahr: | 1 June 2022 |
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| Umfang: | 18 S. |
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| Begleitmaterial: | Supplementary material |
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| Fussnoten: | Gesehen am 24.08.2022 ; This article belongs to the special issue "Mass spectrometry imaging in pharmaceutical research" |
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| Titel Quelle: | Enthalten in: Pharmaceuticals |
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| Ort Quelle: | Basel : MDPI, 2004 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 15(2022), 6, special issue, Artikel-ID 694, Seite 1-18 |
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| ISSN Quelle: | 1424-8247 |
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| Abstract: | Desorption/ionization (DI)-mass spectrometric (MS) methods offer considerable advantages of rapidity and low-sample input for the analysis of solid biological matrices such as tissue sections. The concept of desorption electrospray ionization (DESI) offers the possibility to ionize compounds from solid surfaces at atmospheric pressure, without the addition of organic compounds to initiate desorption. However, severe drawbacks from former DESI hardware stability made the development of assays for drug quantification difficult. In the present study, the potential of new prototype source setups (High Performance DESI Sprayer and Heated Transfer Line) for the development of drug quantification assays in tissue sections was evaluated. It was demonstrated that following dedicated optimization, new DESI XS enhancements present promising options regarding targeted quantitative analyses. As a model compound for these developments, ulixertinib, an inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2 was used. |
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| DOI: | doi:10.3390/ph15060694 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ph15060694 |
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| | Volltext: https://www.mdpi.com/1424-8247/15/6/694 |
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| | DOI: https://doi.org/10.3390/ph15060694 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | desorption electrospray ionization |
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| | drug |
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| | mass spectrometry |
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| | profiling |
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| | quantification |
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| K10plus-PPN: | 1815100788 |
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| Verknüpfungen: | → Zeitschrift |
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Analytical performance evaluation of new DESI enhancements for targeted drug quantification in tissue sections / Fresnais, Margaux [VerfasserIn]; 1 June 2022 (Online-Ressource)
