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Status: Bibliographieeintrag

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Verfasst von:Mileshkin, Linda [VerfasserIn]   i
 Bochtler, Tilmann [VerfasserIn]   i
 Gatta, Gemma [VerfasserIn]   i
 Kurzrock, Razelle [VerfasserIn]   i
 Beringer, Andreas [VerfasserIn]   i
 Müller-Ohldach, Mathis [VerfasserIn]   i
 Surinach, Andy [VerfasserIn]   i
 Perret, Camille [VerfasserIn]   i
 Thomas, Marlene [VerfasserIn]   i
 Gondos, Ádám [VerfasserIn]   i
 Krämer, Alwin [VerfasserIn]   i
Titel:Cancer-of-unknown-primary-origin
Titelzusatz:a SEER-medicare study of patterns of care and outcomes among elderly patients in clinical practice
Verf.angabe:Linda Mileshkin, Tilmann Bochtler, Gemma Gatta, Razelle Kurzrock, Andreas Beringer, Mathis Müller-Ohldach, Andy Surinach, Camille Perret, Marlene Thomas, Adam Gondos and Alwin Krämer
E-Jahr:2022
Jahr:13 June 2022
Umfang:14 S.
Begleitmaterial:Supplementary material
Fussnoten:Gesehen am 25.08.2022
Titel Quelle:Enthalten in: Cancers
Ort Quelle:Basel : MDPI, 2009
Jahr Quelle:2022
Band/Heft Quelle:14(2022), 12, Artikel-ID 2905, Seite 1-14
ISSN Quelle:2072-6694
Abstract:Knowledge of contemporary patterns of cancer-of-unknown-primary-origin (CUP) diagnostic work-up, treatment, and outcomes in routine healthcare is limited. Thus, we examined data from elderly patients diagnosed with CUP in real-world US clinical practice. From the Surveillance, Epidemiology, and End Results-Medicare-linked database, we included patients ≥ 66 years old with CUP diagnosed between 1 January 2013 and 31 December 2015. We analyzed baseline demographics, clinical characteristics, methods of diagnostic work-up (biopsy, immunohistochemistry, imaging), treatment-related factors, and survival. CUP diagnosis was histologically confirmed in 2813/4562 patients (61.7%). Overall, 621/4562 (13.6%) patients received anticancer pharmacotherapy; among these, 97.3% had a histologically confirmed tumor and 83.1% received all three procedures. Among those with a histologically confirmed tumor, increasing age, increasing comorbidity score, not receiving all three diagnostic measures, and having a not-further specified histologic finding of only ‘malignant neoplasm’ were all negatively associated with receipt of anticancer pharmacotherapy. Median overall survival was 1.2 months for all patients. Median time between CUP diagnosis and treatment initiation was 41 days. Limited diagnostic work-up was common and most patients did not receive anticancer pharmacotherapy. The poor outcomes highlight a substantial unmet need for further research into improving diagnostic work-up and treatment effectiveness in CUP.
DOI:doi:10.3390/cancers14122905
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.3390/cancers14122905
 Volltext: https://www.mdpi.com/2072-6694/14/12/2905
 DOI: https://doi.org/10.3390/cancers14122905
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:diagnostic tests and procedures
 drug therapy
 Medicare Part A
 Medicare Part B
 neoplasms
 registries
 SEER program
 survival analysis
 unknown primary
K10plus-PPN:1815171154
Verknüpfungen:→ Zeitschrift

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