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Verfasst von:Kellner, Markus [VerfasserIn]   i
 Peiter, Angela [VerfasserIn]   i
 Hafner, Mathias [VerfasserIn]   i
 Feuring, Martin [VerfasserIn]   i
 Christ, Michael [VerfasserIn]   i
 Wehling, Martin [VerfasserIn]   i
 Falkenstein, Elisabeth [VerfasserIn]   i
 Lösel, Ralf M. [VerfasserIn]   i
Titel:Early aldosterone up-regulated genes
Titelzusatz:new pathways for renal disease
Verf.angabe:Markus Kellner, Angela Peiter, Mathias Hafner, Martin Feuring, Michael Christ, Martin Wehling, Elisabeth Falkenstein, Ralf Lösel
E-Jahr:2003
Jahr:1 October 2003
Umfang:9 S.
Fussnoten:Gesehen am 25.08.2022
Titel Quelle:Enthalten in: Kidney international
Ort Quelle:New York, NY : Elsevier, 1972
Jahr Quelle:2003
Band/Heft Quelle:64(2003), 4, Seite 1199-1207
ISSN Quelle:1523-1755
Abstract:Early aldosterone up-regulated genes: New pathways for renal disease? Background - The use of aldosterone antagonists has important beneficial effects on the progression of renal and cardiac disease reflected in a decrease of cardiovascular mortality and renal failure. Nevertheless, the incidence of heart and end-stage renal failure continues to increase. This leads to the conclusion that mechanisms independent of the classical aldosterone/mineralocorticoid receptor system may contribute to the pathogenesis of cardiac and renal disease. - Methods - The mRNA expression profile of human renal epithelial cells in response to aldosterone was characterized using cDNA arrays covering ∼1430 genes. Differentially expressed genes were further evaluated by quantitative reverse transcription-polymerase chain reaction (RT-PCR), Northern blotting, and estimating the gene products by Western blotting. - Results - Aldosterone treatment of cells resulted in significant up-regulation of several genes within 1 hour, with sgk, p21/waf1, gadd45, and gadd153 being the most significant ones. Long-term treatment (>4 hours) with aldosterone induced the mRNA expression of pparα and purα. The mineralocorticoid receptor inhibitor spironolactone decreased the mRNA levels of sgk, p21/waf1, and gadd45, whereas the glucocorticoid receptor inhibitor RU 486 reduced the mRNA level of sgk and p21/waf1. Gadd153 was not affected by any of the inhibitors, probably indicating regulation by nonclassic mechanisms. - Conclusion - Among the early genes investigated in this study, one transcript has been identified that is not suppressed by antagonists of either glucocorticoid or mineralocorticoid receptor. Further studies should be able to identify other genes regulated in a similar manner that could explain the inefficacy of spironolactone in some cases of aldosterone-mediated kidney disease.
DOI:doi:10.1046/j.1523-1755.2003.00216.x
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1046/j.1523-1755.2003.00216.x
 Volltext: https://www.sciencedirect.com/science/article/pii/S0085253815494554
 DOI: https://doi.org/10.1046/j.1523-1755.2003.00216.x
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:aldosterone
 gene regulation
 kidney
 nonclassic receptors
 renal disease
 spironolactone
K10plus-PPN:1815191171
Verknüpfungen:→ Zeitschrift

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