Neurodevelopment in normocephalic children exposed to Zika virus in utero with no observable defects at birth

• Verfasst von: Marbán-Castro, Elena [VerfasserIn]
• Verfasst von: Vazquez Guillamet, Laia J. [VerfasserIn]
• Verfasst von: Pantoja, Percy Efrain [VerfasserIn]
• Verfasst von: Casellas, Aina [VerfasserIn]
• Verfasst von: Maxwell, Lauren [VerfasserIn]
• Verfasst von: Mulkey, Sarah B. [VerfasserIn]
• Verfasst von: Menéndez, Clara [VerfasserIn]
• Verfasst von: Bardají, Azucena [VerfasserIn]
• Titel: Neurodevelopment in normocephalic children exposed to Zika virus in utero with no observable defects at birth
• Titelzusatz: a systematic review with meta-analysis
• Verf.angabe: Elena Marbán-Castro, Laia J. Vazquez Guillamet, Percy Efrain Pantoja, Aina Casellas, Lauren Maxwell, Sarah B. Mulkey, Clara Menéndez and Azucena Bardají
• E-Jahr: 2022
• Jahr: 14 June 2022
• Umfang: 24 S.
• Begleitmaterial: Supplementary material
• Fussnoten: Gesehen am 25.08.2022 ; This article belongs to the special issue "Frontiers in maternal and reproductive health"
• Titel Quelle: Enthalten in: International journal of environmental research and public health
• Ort Quelle: Basel : MDPI AG, 2004
• Jahr Quelle: 2022
• Band/Heft Quelle: 19(2022), 12, special issue, Artikel-ID 7319, Seite 1-24
• ISSN Quelle: 1660-4601
• DOI: doi:10.3390/ijerph19127319
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: cognitive
• Sach-SW: delay
• Sach-SW: language
• Sach-SW: motor
• Sach-SW: neurodevelopment
• Sach-SW: normocephalic
• Sach-SW: Zika
• K10plus-PPN: 1815192917

Abstract

Zika virus (ZIKV) infection during pregnancy is a cause of pregnancy loss and multiple clinical and neurological anomalies in children. This systematic review aimed to assess the effect of ZIKV exposure in utero on the long-term neurodevelopment of normocephalic children born to women with ZIKV infection in pregnancy. This review was conducted according to the PRISMA guidelines for systematic reviews and meta-analyses. We performed a random effects meta-analysis to estimate the cross-study prevalence of neurodevelopmental delays in children using the Bayley Scales for Infant and Toddler Development (BSID-III). The risk of bias was assessed using Cochrane’s Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Full-text reviews were performed for 566 articles, and data were extracted from 22 articles corresponding to 20 studies. Nine articles including data from 476 children found 6.5% (95% CI: 4.1-9.3) of infants and children to have any type of non-language cognitive delay; 29.7% (95% CI: 21.7-38.2) to have language delay; and 11.5% (95% CI: 4.8-20.1) to have any type of motor delay. The pooled estimates had a high level of heterogeneity; thus, results should be interpreted with caution. Larger prospective studies that include a non-exposed control group are needed to confirm whether ZIKV exposure in utero is associated with adverse child neurodevelopmental outcomes.