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| Verfasst von: | Morcos, Mina [VerfasserIn]  |
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| | Li, Congxin [VerfasserIn] |
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| | Munz, Clara M. [VerfasserIn] |
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| | Greco, Alessandro [VerfasserIn] |
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| | Dressel, Nicole [VerfasserIn] |
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| | Reinhardt, Susanne [VerfasserIn] |
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| | Sameith, Katrin [VerfasserIn] |
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| | Dahl, Andreas [VerfasserIn] |
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| | Becker, Nils B. [VerfasserIn] |
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| | Roers, Axel [VerfasserIn] |
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| | Höfer, Thomas [VerfasserIn] |
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| | Gerbaulet, Alexander [VerfasserIn] |
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| Titel: | Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis |
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| Verf.angabe: | Mina N.F. Morcos, Congxin Li, Clara M. Munz, Alessandro Greco, Nicole Dressel, Susanne Reinhardt, Katrin Sameith, Andreas Dahl, Nils B. Becker, Axel Roers, Thomas Höfer & Alexander Gerbaulet |
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| E-Jahr: | 2022 |
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| Jahr: | 03 August 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 28.08.2022 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022), Artikel-ID 4504, Seite 1-13 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart native lineage pathways emanating from HSCs and define their physiological regulation by computationally integrating experimental approaches for fate mapping, mitotic tracking, and single-cell RNA sequencing. We find that lineages begin to split when cells leave the tip HSC population, marked by high Sca-1 and CD201 expression. Downstream, HSCs either retain high Sca-1 expression and the ability to generate lymphocytes, or irreversibly reduce Sca-1 level and enter into erythro-myelopoiesis or thrombopoiesis. Thrombopoiesis is the sum of two pathways that make comparable contributions in steady state, a long route via multipotent progenitors and CD48hi megakaryocyte progenitors (MkPs), and a short route from HSCs to developmentally distinct CD48−/lo MkPs. Enhanced thrombopoietin signaling differentially accelerates the short pathway, enabling a rapid response to increasing demand. In sum, we provide a blueprint for mapping physiological differentiation fluxes from HSCs and decipher two functionally distinct pathways of native thrombopoiesis. |
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| DOI: | doi:10.1038/s41467-022-31914-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41467-022-31914-z |
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| | Volltext: https://www.nature.com/articles/s41467-022-31914-z |
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| | DOI: https://doi.org/10.1038/s41467-022-31914-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Computational models |
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| | Haematopoietic stem cells |
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| | Platelets |
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| K10plus-PPN: | 1815283343 |
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| Verknüpfungen: | → Zeitschrift |
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Fate mapping of hematopoietic stem cells reveals two pathways of native thrombopoiesis / Morcos, Mina [VerfasserIn]; 03 August 2022 (Online-Ressource)
