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Verfasst von:Tini, Elvira [VerfasserIn]   i
 Smigielski, Lukasz [VerfasserIn]   i
 Romanos, Marcel [VerfasserIn]   i
 Wewetzer, Christoph [VerfasserIn]   i
 Karwautz, Andreas [VerfasserIn]   i
 Reitzle, Karl [VerfasserIn]   i
 Correll, Christoph U. [VerfasserIn]   i
 Plener, Paul L. [VerfasserIn]   i
 Malzahn, Uwe [VerfasserIn]   i
 Heuschmann, Peter [VerfasserIn]   i
 Unterecker, Stefan [VerfasserIn]   i
 Scherf-Clavel, Maike [VerfasserIn]   i
 Rock, Hans [VerfasserIn]   i
 Antony, Gisela [VerfasserIn]   i
 Briegel, Wolfgang [VerfasserIn]   i
 Fleischhaker, Christian [VerfasserIn]   i
 Banaschewski, Tobias [VerfasserIn]   i
 Hellenschmidt, Tobias [VerfasserIn]   i
 Imgart, Hartmut [VerfasserIn]   i
 Kaess, Michael [VerfasserIn]   i
 Kölch, Michael [VerfasserIn]   i
 Renner, Tobias [VerfasserIn]   i
 Reuter-Dang, Su-Yin [VerfasserIn]   i
 Rexroth, Christian [VerfasserIn]   i
 Schulte-Körne, Gerd [VerfasserIn]   i
 Theisen, Frank [VerfasserIn]   i
 Fekete, Stefanie [VerfasserIn]   i
 Taurines, Regina [VerfasserIn]   i
 Gerlach, Manfred [VerfasserIn]   i
 Egberts, Karin M. [VerfasserIn]   i
 Walitza, Susanne [VerfasserIn]   i
Titel:Therapeutic drug monitoring of sertraline in children and adolescents
Titelzusatz:a naturalistic study with insights into the clinical response and treatment of obsessive-compulsive disorder
Verf.angabe:Elvira Tini, Lukasz Smigielski, Marcel Romanos, Christoph Wewetzer, Andreas Karwautz, Karl Reitzle, Christoph U. Correll, Paul L. Plener, Uwe Malzahn, Peter Heuschmann, Stefan Unterecker, Maike Scherf-Clavel, Hans Rock, Gisela Antony, Wolfgang Briegel, Christian Fleischhaker, Tobias Banaschewski, Tobias Hellenschmidt, Hartmut Imgart, Michael Kaess, Michael Kölch, Tobias Renner, Su-Yin Reuter-Dang, Christian Rexroth, Gerd Schulte-Körne, Frank Theisen, Stefanie Fekete, Regina Taurines, Manfred Gerlach, Karin Maria Egberts, Susanne Walitza
E-Jahr:2022
Jahr:26 February 2022
Umfang:11 S.
Fussnoten:Gesehen am 29.08.2022
Titel Quelle:Enthalten in: Comprehensive psychiatry
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1960
Jahr Quelle:2022
Band/Heft Quelle:115(2022), Artikel-ID 152301, Seite 1-11
ISSN Quelle:1532-8384
Abstract:BACKGROUND: Sertraline is a selective serotonin reuptake inhibitor with specific indications in child and adolescent psychiatry. Notwithstanding its frequent use and clinical benefits, the relationship between pharmacokinetics, pharmacodynamics, efficacy, and tolerability of sertraline across indications, particularly in non-adult patients, is not fully understood. - METHOD: This naturalistic therapeutic drug monitoring (TDM) study was conducted in a transdiagnostic sample of children and adolescents treated with sertraline (n = 78; mean age, 14.22 ± 2.39; range, 7-18 years) within the prospective multicenter "TDM-VIGIL" project. Associations between dose, serum concentration, and medication-specific therapeutic and side effects based on the Clinical Global Impression scale were examined. Tolerability was measured qualitatively with the 56-item Pediatric Adverse Event Rating Scale. - RESULTS: A strong linear positive dose-serum concentration relationship (with dose explaining 45% of the variance in concentration) and significant effects of weight and co-medication were found. Neither dose nor serum concentration were associated with side effects. An overall mild-to-moderate tolerability profile of sertraline was observed. In contrast with the transdiagnostic analysis that did not indicate an effect of concentration, when split into depression (MDD) and obsessive-compulsive disorder (OCD) diagnoses, the probability of clinical improvement significantly increased as both dose and concentration increased for OCD, but not for MDD. - CONCLUSIONS: This TDM-flexible-dose study revealed a significant diagnosis-specific effect between sertraline serum concentration and clinical efficacy for pediatric OCD. While TDM already guides clinical decision-making regarding compliance, dose calibration, and drug-drug interactions, combining TDM with other methods, such as pharmacogenetics, may facilitate a personalized medicine approach in psychiatry.
DOI:doi:10.1016/j.comppsych.2022.152301
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.comppsych.2022.152301
 DOI: https://doi.org/10.1016/j.comppsych.2022.152301
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Adolescent
 antidepressants
 Child
 Drug Monitoring
 Humans
 Obsessive-Compulsive Disorder
 pharmacovigilance
 Prospective Studies
 selective serotonin reuptake inhibitors
 Serotonin Uptake Inhibitors
 Sertraline
 steady state concentration
 TDM
K10plus-PPN:1815324317
Verknüpfungen:→ Zeitschrift

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