Neurostructural traces of early life adversities

• Verfasst von: Pollok, Tania [VerfasserIn]
• Verfasst von: Kaiser, Anna [VerfasserIn]
• Verfasst von: Kraaijenvanger, Eline J. [VerfasserIn]
• Verfasst von: Monninger, Maximilian [VerfasserIn]
• Verfasst von: Brandeis, Daniel [VerfasserIn]
• Verfasst von: Banaschewski, Tobias [VerfasserIn]
• Verfasst von: Eickhoff, Simon B. [VerfasserIn]
• Verfasst von: Holz, Nathalie E. [VerfasserIn]
• Titel: Neurostructural traces of early life adversities
• Titelzusatz: a meta-analysis exploring age- and adversity-specific effects
• Verf.angabe: Tania M. Pollok, Anna Kaiser, Eline J. Kraaijenvanger, Maximilian Monninger, Daniel Brandeis, Tobias Banaschewski, Simon B. Eickhoff, Nathalie E. Holz
• E-Jahr: 2022
• Jahr: 18 February 2022
• Umfang: 15 S.
• Fussnoten: Gesehen am 30.08.2022
• Titel Quelle: Enthalten in: Neuroscience & biobehavioral reviews
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1978
• Jahr Quelle: 2022
• Band/Heft Quelle: 135(2022), Artikel-ID 104589, Seite 1-15
• ISSN Quelle: 1873-7528
• DOI: doi:10.1016/j.neubiorev.2022.104589
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adolescent
• Sach-SW: Adult
• Sach-SW: Brain
• Sach-SW: Child
• Sach-SW: Childhood adversity
• Sach-SW: Early life stress
• Sach-SW: Emotions
• Sach-SW: Gray Matter
• Sach-SW: Humans
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Magnetic Resonance Imaging
• Sach-SW: Temporal Lobe
• K10plus-PPN: 1815382147

Abstract

Early life adversities (ELAs) are associated with an increased risk of psychopathology, with studies suggesting a relation to structural brain alterations. Given the recently growing evidence of ELA effects on brain structure, an updated summary is highly warranted. Therefore, anatomical likelihood estimation was used to conduct a coordinate-based meta-analysis of gray matter volume (GMV) alterations associated with ELAs, including sub-analyses for different age groups and maltreatment as specific ELA-type. The analyses uncovered a convergence of pooled ELA-effects on GMV in the right hippocampus and amygdala and the left inferior frontal gyrus, age-specific effects for the right amygdala and hippocampus in children and adolescents, and maltreatment-specific effects for the right perigenual anterior cingulate cortex in adults. These results reveal a possible underlying commonality in the impact of adversity and also point to specific age and maltreatment effects. They suggest neural markers of ELAs in regions involved in socio-emotional functioning and stress regulation, with the potential to be used as targets for interventions designed to buffer or reverse harmful ELA-effects.