| |  Online-Ressource |
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| Verfasst von: | Garreta, Elena [VerfasserIn]  |
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| | Prado, Patricia [VerfasserIn] |
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| | Stanifer, Megan [VerfasserIn] |
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| | Monteil, Vanessa [VerfasserIn] |
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| | Marco, Andrés [VerfasserIn] |
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| | Ullate-Agote, Asier [VerfasserIn] |
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| | Moya-Rull, Daniel [VerfasserIn] |
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| | Vilas-Zornoza, Amaia [VerfasserIn] |
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| | Tarantino, Carolina [VerfasserIn] |
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| | Romero, Juan Pablo [VerfasserIn] |
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| | Jonsson, Gustav [VerfasserIn] |
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| | Oria, Roger [VerfasserIn] |
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| | Leopoldi, Alexandra [VerfasserIn] |
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| | Hagelkruys, Astrid [VerfasserIn] |
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| | Gallo, Maria [VerfasserIn] |
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| | González, Federico [VerfasserIn] |
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| | Domingo-Pedrol, Pere [VerfasserIn] |
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| | Gavaldà, Aleix [VerfasserIn] |
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| | Pozo, Carmen Hurtado del [VerfasserIn] |
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| | Hasan Ali, Omar [VerfasserIn] |
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| | Ventura-Aguiar, Pedro [VerfasserIn] |
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| | Campistol, Josep María [VerfasserIn] |
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| | Prosper, Felipe [VerfasserIn] |
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| | Mirazimi, Ali [VerfasserIn] |
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| | Boulant, Steeve [VerfasserIn] |
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| | Penninger, Josef M. [VerfasserIn] |
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| | Montserrat, Nuria [VerfasserIn] |
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| Titel: | A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells |
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| Verf.angabe: | Elena Garreta, Patricia Prado, Megan L. Stanifer, Vanessa Monteil, Andrés Marco, Asier Ullate-Agote, Daniel Moya-Rull, Amaia Vilas-Zornoza, Carolina Tarantino, Juan Pablo Romero, Gustav Jonsson, Roger Oria, Alexandra Leopoldi, Astrid Hagelkruys, Maria Gallo, Federico González, Pere Domingo-Pedrol, Aleix Gavaldà, Carmen Hurtado del Pozo, Omar Hasan Ali, Pedro Ventura-Aguiar, Josep María Campistol, Felipe Prosper, Ali Mirazimi, Steeve Boulant, Josef M. Penninger, and Nuria Montserrat |
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| E-Jahr: | 2022 |
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| Jahr: | 12 May 2022 |
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| Umfang: | 26 S. |
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| Fussnoten: | Gesehen am 31.08.2022 |
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| Titel Quelle: | Enthalten in: Cell metabolism |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2005 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 34(2022), 6 vom: Juni, Seite 857-873, e1-e9 |
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| ISSN Quelle: | 1932-7420 |
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| Abstract: | It is not well understood why diabetic individuals are more prone to develop severe COVID-19. To this, we here established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development. Upon SARS-CoV-2 infection, diabetic-like kidney organoids exhibited higher viral loads compared with their control counterparts. Genetic deletion of the angiotensin-converting enzyme 2 (ACE2) in kidney organoids under control or diabetic-like conditions prevented viral detection. Moreover, cells isolated from kidney biopsies from diabetic patients exhibited altered mitochondrial respiration and enhanced glycolysis, resulting in higher SARS-CoV-2 infections compared with non-diabetic cells. Conversely, the exposure of patient cells to dichloroacetate (DCA), an inhibitor of aerobic glycolysis, resulted in reduced SARS-CoV-2 infections. Our results provide insights into the identification of diabetic-induced metabolic programming in the kidney as a critical event increasing SARS-CoV-2 infection susceptibility, opening the door to the identification of new interventions in COVID-19 pathogenesis targeting energy metabolism. |
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| DOI: | doi:10.1016/j.cmet.2022.04.009 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.cmet.2022.04.009 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S155041312200136X |
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| | DOI: https://doi.org/10.1016/j.cmet.2022.04.009 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ACE2 |
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| | angiotensin-converting enzyme 2 |
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| | COVID-19 |
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| | diabetes 2 |
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| | human kidney organoids |
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| | SARS-CoV-2 |
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| K10plus-PPN: | 1815474947 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells / Garreta, Elena [VerfasserIn]; 12 May 2022 (Online-Ressource)
