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| Verfasst von: | Rasche, Leo [VerfasserIn]  |
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| | Schinke, Carolina [VerfasserIn] |
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| | Maura, Francesco [VerfasserIn] |
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| | Bauer, Michael A. [VerfasserIn] |
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| | Ashby, Cody [VerfasserIn] |
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| | Deshpande, Shayu [VerfasserIn] |
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| | Poos, Alexandra [VerfasserIn] |
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| | Zangari, Maurizio [VerfasserIn] |
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| | Thanendrarajan, Sharmilan [VerfasserIn] |
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| | Davies, Faith E. [VerfasserIn] |
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| | Walker, Brian A. [VerfasserIn] |
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| | Barlogie, Bart [VerfasserIn] |
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| | Landgren, Ola [VerfasserIn] |
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| | Morgan, Gareth J. [VerfasserIn] |
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| | van Rhee, Frits [VerfasserIn] |
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| | Weinhold, Niels [VerfasserIn] |
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| Titel: | The spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states |
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| Verf.angabe: | Leo Rasche, Carolina Schinke, Francesco Maura, Michael A. Bauer, Cody Ashby, Shayu Deshpande, Alexandra M. Poos, Maurizio Zangari, Sharmilan Thanendrarajan, Faith E. Davies, Brian A. Walker, Bart Barlogie, Ola Landgren, Gareth J. Morgan, Frits van Rhee & Niels Weinhold |
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| E-Jahr: | 2022 |
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| Jahr: | 03 August 2022 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 01.09.2022 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Springer Nature, 2010 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 13(2022), Artikel-ID 4517, Seite 1-13 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Deciphering Multiple Myeloma evolution in the whole bone marrow is key to inform curative strategies. Here, we perform spatial-longitudinal whole-exome sequencing, including 140 samples collected from 24 Multiple Myeloma patients during up to 14 years. Applying imaging-guided sampling we observe three evolutionary patterns, including relapse driven by a single-cell expansion, competing/co-existing sub-clones, and unique sub-clones at distinct locations. While we do not find the unique relapse sub-clone in the baseline focal lesion(s), we show a close phylogenetic relationship between baseline focal lesions and relapse disease, highlighting focal lesions as hotspots of tumor evolution. In patients with ≥3 focal lesions on positron-emission-tomography at diagnosis, relapse is driven by multiple distinct sub-clones, whereas in other patients, a single-cell expansion is typically seen (p < 0.01). Notably, we observe resistant sub-clones that can be hidden over years, suggesting that a prerequisite for curative therapies would be to overcome not only tumor heterogeneity but also dormancy. |
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| DOI: | doi:10.1038/s41467-022-32145-y |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1038/s41467-022-32145-y |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41467-022-32145-y |
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| | DOI: https://doi.org/10.1038/s41467-022-32145-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cancer genomics |
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| | Cancer imaging |
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| | Myeloma |
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| | Tumour heterogeneity |
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| K10plus-PPN: | 1815589051 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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¬The¬ spatio-temporal evolution of multiple myeloma from baseline to relapse-refractory states / Rasche, Leo [VerfasserIn]; 03 August 2022 (Online-Ressource)
