| Online-Ressource |
Verfasst von: | Krüchten, Ricarda von [VerfasserIn]  |
| Lorbeer, Roberto [VerfasserIn]  |
| Müller-Peltzer, Katharina [VerfasserIn]  |
| Rospleszcz, Susanne [VerfasserIn]  |
| Storz, Corinna [VerfasserIn]  |
| Askani, Esther [VerfasserIn]  |
| Kulka, Charlotte [VerfasserIn]  |
| Schuppert, Christopher [VerfasserIn]  |
| Rathmann, Wolfgang [VerfasserIn]  |
| Peters, Annette [VerfasserIn]  |
| Bamberg, Fabian [VerfasserIn]  |
| Schlett, Christopher L. [VerfasserIn]  |
| Mujaj, Blerim [VerfasserIn]  |
Titel: | Association between adipose tissue depots and dyslipidemia |
Titelzusatz: | the KORA-MRI population-based study |
Verf.angabe: | Ricarda von Krüchten, Roberto Lorbeer, Katharina Müller-Peltzer, Susanne Rospleszcz, Corinna Storz, Esther Askani, Charlotte Kulka, Christopher Schuppert, Wolfgang Rathmann, Annette Peters, Fabian Bamberg, Christopher L. Schlett and Blerim Mujaj |
E-Jahr: | 2022 |
Jahr: | 14 February 2022 |
Umfang: | 12 S. |
Fussnoten: | Gesehen am 02.09.2022 |
Titel Quelle: | Enthalten in: Nutrients |
Ort Quelle: | Basel : MDPI, 2009 |
Jahr Quelle: | 2022 |
Band/Heft Quelle: | 14(2022), 4, Artikel-ID 797, Seite 1-12 |
ISSN Quelle: | 2072-6643 |
Abstract: | Obesity increases the risk of cardiovascular diseases (CVD), however, whether adipose tissue relates to dyslipidemia, and consequently to cardiovascular events remains unknown. Thus, we investigated the association of adipose tissue with circulating lipoproteins and triglycerides (TG) in subjects without CVD. 384 participants from the KORA-MRI study (mean age 56.2 ± 9.2 years; 41.9% female) underwent whole-body 3T-MRI. Visceral (VAT) and subcutaneous adipose tissue (SAT) derived from T1-DIXON-sequence using a semi-automatic algorithm. Total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and TG were measured. Linear regression was applied to examine the relationships between adipose tissue, circulating lipoproteins, and TG, adjusting for risk factors. VAT was associated with total cholesterol (per SD increase) (ß = 0.39, p < 0.001). Total adipose tissue (TAT) and VAT were inversely associated with HDL (ß = -0.09, p = 0.009; ß = -0.14, p < 0.001), and positively associated with LDL (ß = 0.32, p < 0.001; ß = 0.37, p < 0.001). All adipose tissues were associated with TG (ß = 0.20, p < 0.001; ß = 0.27, p < 0.001; ß = 0.11, p = 0.004). Stratified analysis by sex and body mass index (BMI) was confirmatory in women and in individuals with BMI < 30. Our results suggest that adipose tissue plays an important role in increasing CVD risk independent of BMI, whereas gender imbalance may be explained by accurate characterization and quantification of adipose tissue. |
DOI: | doi:10.3390/nu14040797 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/nu14040797 |
| DOI: https://doi.org/10.3390/nu14040797 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | adipose tissue |
| Adipose Tissue |
| Aged |
| Body Mass Index |
| Dyslipidemias |
| Female |
| HDL-cholesterol |
| Humans |
| Intra-Abdominal Fat |
| LDL-cholesterol |
| magnetic resonance imaging |
| Magnetic Resonance Imaging |
| Male |
| Middle Aged |
| population-based cohort |
| Subcutaneous Fat |
| total cholesterol |
| triglycerides |
K10plus-PPN: | 1815694807 |
Verknüpfungen: | → Zeitschrift |
Association between adipose tissue depots and dyslipidemia / Krüchten, Ricarda von [VerfasserIn]; 14 February 2022 (Online-Ressource)