Impact of SARS-CoV-2 on pregnancy and neonatal outcomes

• Verfasst von: Gomez, Ursula [VerfasserIn]
• Verfasst von: Francisco, Rossana Pulcineli Vieira [VerfasserIn]
• Verfasst von: Baptista, Fernanda Spadotto [VerfasserIn]
• Verfasst von: Gibelli, Maria Augusta B. C. [VerfasserIn]
• Verfasst von: Ibidi, Silvia Maria [VerfasserIn]
• Verfasst von: Carvalho, Werther Brunow de [VerfasserIn]
• Verfasst von: Paganoti, Cristiane de Freitas [VerfasserIn]
• Verfasst von: Sabino, Ester Cerdeira [VerfasserIn]
• Verfasst von: Silva, Lea Campos de Oliveira da [VerfasserIn]
• Verfasst von: Jänisch, Thomas [VerfasserIn]
• Verfasst von: Mayaud, Philippe [VerfasserIn]
• Verfasst von: Brizot, Maria de Lourdes [VerfasserIn]
• Titel: Impact of SARS-CoV-2 on pregnancy and neonatal outcomes
• Titelzusatz: an open prospective study of pregnant women in Brazil
• Verf.angabe: Ursula Trovato Gomez, Rossana Pulcineli Vieira Francisco, Fernanda Spadotto Baptista, Maria Augusta B. C. Gibelli, Silvia Maria Ibidi, Werther Brunow de Carvalho, Cristiane de Freitas Paganoti, Ester Cerdeira Sabino, Lea Campos de Oliveira da Silva, Thomas Jaenisch, Philippe Mayaud, Maria de Lourdes Brizot, and the HC-FMUSP-Obstetric COVID-19 Study Group
• E-Jahr: 2022
• Jahr: 27 June 2022
• Umfang: 9 S.
• Fussnoten: HC-FMUSP-Obstetric COVID-19 Study Group: Aline Scalisse Bassi, Amanda Wictky Fabri, Ana Claudia Rodrigues Lopes Amaral de Souza, Ana Claudia Silva Farche, Ana Maria Kondo Igai, Ana Maria da Silva Sousa Oliveira, Adriana Lippi Waissman, Carlos Eduardo do Nascimento Martins, Danielle Rodrigues Domingues, Fernanda Cristina Ferreira Mikami, Jacqueline Kobayashi Cippiciani, Jessica Gorrao Lopes Albertini, Juliana Ikeda Niigaki, Marco Aurelio Knippel Galleta, Mariana Yumi Miyadahira, Mariana Vieira Barbosa, Mariane de Fatima Yukie Maeda, Monica Fairbanks de Barros, Nilton Hideto Takiuti, Silvio Martinelli, Stela Verzinhas Peres, Tiago Pedromonico Arrym, Veridiana Freire Franco ; Gesehen am 02.09.2022
• Titel Quelle: Enthalten in: Clinics
• Ort Quelle: São Paulo : Univ., 2005
• Jahr Quelle: 2022
• Band/Heft Quelle: 77(2022), Artikel-ID 100073, Seite 1-9
• ISSN Quelle: 1980-5322
• DOI: doi:10.1016/j.clinsp.2022.100073
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Brazil
• Sach-SW: COVID-19
• Sach-SW: Female
• Sach-SW: Humans
• Sach-SW: Infant, Newborn
• Sach-SW: Neonatal
• Sach-SW: Obstetric
• Sach-SW: Oligohydramnios
• Sach-SW: Outcome
• Sach-SW: Pregnancy
• Sach-SW: Pregnancy Complications, Infectious
• Sach-SW: Pregnancy Outcome
• Sach-SW: Pregnant Women
• Sach-SW: Premature Birth
• Sach-SW: Prospective Studies
• Sach-SW: SARS-CoV-2
• Sach-SW: SARS-CoV-2 Infection
• K10plus-PPN: 1815702060

Abstract

OBJECTIVES: To determine the incidence and risk of adverse obstetric and neonatal outcomes according to SARS-CoV-2 infection severity in pregnant women. - METHOD: Open prospective study of pregnant women tested for SARS-CoV-2 by serological and molecular assays during pregnancy or delivery in two hospitals in Sao Paulo, Brazil from April 12, 2020, to February 28, 2021. Five groups were considered for analysis: C0, negative COVID-19 results and no COVID-19 symptoms; C1, positive COVID-19 results, and no symptoms; C2, positive COVID-19 results with mild symptoms; C3, positive COVID-19 results with moderate symptoms; and C4, positive COVID-19 results with severe symptoms. The association between obstetric and neonatal outcomes and COVID-19 severity was determined using multivariate analysis. - RESULTS: 734 eligible pregnant women were enrolled as follows: C0 (n = 357), C1 (n = 127), C2 (n = 174), C3 (n = 37), and C4 (n = 39). The following pregnancy and neonatal outcomes were associated with severe COVID-19: oligohydramnios (adjusted Odds Ratio [aOR] = 6.18; 95% CI 1.87‒20.39), fetal distress (aOR = 4.01; 95% Confidence Interval [CI] 1.84‒8.75), preterm birth (aOR = 5.51; 95% CI 1.47‒20.61), longer hospital stay (aOR = 1.66; 95% CI 1.36‒2.02), and admission to the neonatal intensive care unit (aOR = 19.36; 95% CI, 5.86‒63.99). All maternal (n = 6, 15.4%, p < 0.001) and neonatal (n = 5, 12.5%, p < 0.001) deaths and most fetal deaths (n = 4, 9.8%, p < 0.001) occurred in C4 group. Moderate COVID-19 was associated with oligohydramnios (aOR = 6.23; 95% CI 1.93‒20.13) and preterm birth (aOR = 3.60; 95% CI 1.45‒9.27). Mild COVID-19 was associated with oligohydramnios (aOR = 3.77; 95% CI 1.56‒9.07). - CONCLUSION: Adverse pregnancy and neonatal outcomes were associated with maternal symptomatic COVID-19 status, and risk increased with disease severity.