Influence of diffusion on transverse relaxation rates and phases of an ensemble of magnetic spheres

• Verfasst von: Rotkopf, Lukas Thomas [VerfasserIn]
• Verfasst von: Buschle, Lukas R. [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Ziener, Christian H. [VerfasserIn]
• Titel: Influence of diffusion on transverse relaxation rates and phases of an ensemble of magnetic spheres
• Verf.angabe: L.T. Rotkopf, L.R. Buschle, H.-P. Schlemmer, C.H. Ziener
• E-Jahr: 2022
• Jahr: 23 June 2022
• Umfang: 12 S.
• Fussnoten: Gesehen am 07.09.2022
• Titel Quelle: Enthalten in: Journal of magnetic resonance
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1969
• Jahr Quelle: 2022
• Band/Heft Quelle: 341(2022), Artikel-ID 107259, Seite 1-12
• ISSN Quelle: 1096-0856
• DOI: doi:10.1016/j.jmr.2022.107259
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Diffusion-weighted imaging
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Magnetic susceptibility
• Sach-SW: Quantitative susceptibility mapping
• K10plus-PPN: 1815958952

Abstract

In quantitative susceptibility mapping, the tissue susceptibility is determined from the magnitude and phase of the gradient echo signal, which is influenced by the interplay of complex susceptibility and diffusion effect. Herein, we analytically analyze the influence of diffusion on magnitude and phase images generated by randomly arranged magnetic spheres as a model of intracerebral iron depositions. We demonstrate that both gradient and spin echo relaxation rate constants have a strong and nonlinear dependence on diffusion strength and give empirical formulas for magnitude and phase. This may be used in the future to improve QSM processing methods. In addition, we show that, in theory, combined acquisitions of gradient and spin echo can be used to determine the dimension of the magnetic spheres and the diffusion strength.