| |  Online-Ressource |
|---|
| Verfasst von: | Hashmi, A. Stephen K. [VerfasserIn]  |
|---|
| | Riedel, Dominic [VerfasserIn] |
|---|
| | Grundl, Marc A. [VerfasserIn] |
|---|
| | Wittel, Bärbel C. [VerfasserIn] |
|---|
| | Föll, Andreas [VerfasserIn] |
|---|
| | Lubkoll, Jana [VerfasserIn] |
|---|
| | Traut, Telisha [VerfasserIn] |
|---|
| | Hewer, Raymond [VerfasserIn] |
|---|
| | Rominger, Frank [VerfasserIn] |
|---|
| | Frey, Wolfgang [VerfasserIn] |
|---|
| | Bats, Jan W. [VerfasserIn] |
|---|
| Titel: | Bioconjugates of enantiomerically pure organopalladium compounds by metal-assisted positional selective transesterifications at palladium enolates |
|---|
| Verf.angabe: | A. Stephen K. Hashmi, Dominic Riedel, Marc A. Grundl, Bärbel C. Wittel, Andreas Föll, Jana Lubkoll, Telisha Traut, Raymond Hewer, Frank Rominger, Wolfgang Frey, and Jan W. Bats |
|---|
| E-Jahr: | 2011 |
|---|
| Jahr: | 21 April 2011 |
|---|
| Umfang: | 8 S. |
|---|
| Fussnoten: | Gesehen am 07.09.2022 |
|---|
| Titel Quelle: | Enthalten in: Chemistry - a European journal |
|---|
| Ort Quelle: | Weinheim : Wiley-VCH, 1995 |
|---|
| Jahr Quelle: | 2011 |
|---|
| Band/Heft Quelle: | 17(2011), 23, Seite 6407-6414 |
|---|
| ISSN Quelle: | 1521-3765 |
|---|
| Abstract: | The synthesis of enantiomerically pure palladatricyclo[4.1.0.02,4]heptanes and their modification by an unprecedented and very efficient positional selective transesterification is described. The mild reaction conditions are most probably based on an acceleration of the transesterification due to assistance by the metal. This novel approach allows straightforward access to a large number of structurally diverse organometallic complexes. The functional groups on the newly installed ester moieties were modified by using standard peptide synthesis protocols, Sonogashira reactions, and nucleophilic substitution reactions. The cellular uptake of these organometallic species was traced by confocal microscopy and their biological activity was evaluated by using different cell lines. Inhibition of cell growth and induction of apoptotic cell death by these novel palladium heterocycles are equivalent to Cisplatin. |
|---|
| DOI: | doi:10.1002/chem.201003308 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1002/chem.201003308 |
|---|
| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201003308 |
|---|
| | DOI: https://doi.org/10.1002/chem.201003308 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Bioconjugates of enantiomerically pure organopalladium compounds by metal-assisted positional selective transesterifications at palladium enolates. - 2011 |
|---|
| Sach-SW: | acids |
|---|
| | alcohols |
|---|
| | coordination compounds |
|---|
| | metallacycles |
|---|
| | palladium |
|---|
| K10plus-PPN: | 1815988231 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Bioconjugates of enantiomerically pure organopalladium compounds by metal-assisted positional selective transesterifications at palladium enolates / Hashmi, A. Stephen K. [VerfasserIn]; 21 April 2011 (Online-Ressource)
