Status: Bibliographieeintrag
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| Verfasst von: | Missirlis, Dimitris [VerfasserIn]  |
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| | Heckmann, Lara [VerfasserIn] |
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| | Haraszti, Tamás [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| Titel: | Fibronectin anchoring to viscoelastic poly(dimethylsiloxane) elastomers controls fibroblast mechanosensing and directional motility |
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| Verf.angabe: | Dimitris Missirlis, Lara Heckmann, Tamás Haraszti, Joachim P. Spatz |
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| E-Jahr: | 2022 |
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| Jahr: | 27 June 2022 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 07.09.2022 |
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| Titel Quelle: | Enthalten in: Biomaterials |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1980 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 287(2022), Artikel-ID 121646, Seite 1-11 |
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| ISSN Quelle: | 0142-9612 |
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| Abstract: | The established link between deregulated tissue mechanics and various pathological states calls for the elucidation of the processes through which cells interrogate and interpret the mechanical properties of their microenvironment. In this work, we demonstrate that changes in the presentation of the extracellular matrix protein fibronectin on the surface of viscoelastic silicone elastomers have an overarching effect on cell mechanosensing, that is independent of bulk mechanics. Reduction of surface hydrophilicity resulted in altered fibronectin adsorption strength as monitored using atomic force microscopy imaging and pulling experiments. Consequently, primary human fibroblasts were able to remodel the fibronectin coating, adopt a polarized phenotype and migrate directionally even on soft elastomers, that otherwise were not able to resist the applied traction forces. The findings presented here provide valuable insight on how cellular forces are regulated by ligand presentation and used by cells to probe their mechanical environment, and have implications on biomaterial design for cell guidance. |
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| DOI: | doi:10.1016/j.biomaterials.2022.121646 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.biomaterials.2022.121646 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0142961222002861 |
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| | DOI: https://doi.org/10.1016/j.biomaterials.2022.121646 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1815997400 |
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| Verknüpfungen: | → Zeitschrift |
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Fibronectin anchoring to viscoelastic poly(dimethylsiloxane) elastomers controls fibroblast mechanosensing and directional motility / Missirlis, Dimitris [VerfasserIn]; 27 June 2022 (Online-Ressource)
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