Kidney transplantation for high-risk sensitized patients - the “Heidelberg Algorithm”

• Verfasst von: Morath, Christian [VerfasserIn]
• Verfasst von: Opelz, Gerhard [VerfasserIn]
• Verfasst von: Zeier, Martin [VerfasserIn]
• Verfasst von: Süsal, Caner [VerfasserIn]
• Titel: Kidney transplantation for high-risk sensitized patients - the “Heidelberg Algorithm”
• Verf.angabe: C. Morath, G. Opelz, M. Zeier, and C. Süsal
• E-Jahr: 2011
• Jahr: 12 April 2011
• Umfang: 4 S.
• Fussnoten: Gesehen am 07.09.2022
• Titel Quelle: Enthalten in: Transplantation proceedings
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1997
• Jahr Quelle: 2011
• Band/Heft Quelle: 43(2011), 3 vom: Apr., Seite 801-804
• ISSN Quelle: 1873-2623
• DOI: doi:10.1016/j.transproceed.2011.02.074
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1815999810

Abstract

Presensitized patients on kidney transplant waiting lists have a lower chance of receiving a crossmatch-negative kidney and, if transplanted, are at increased risk of immunologic graft loss. We developed an algorithm for pretransplant risk estimation and peritransplant treatment which contains 7 independent steps: 1) pretransplant identification of high-risk patients; 2) good HLA match; 3) inclusion in the Acceptable Mismatch Program of Eurotransplant if applicable; 4 and 5) pre- and posttransplantation desensitization; 6) monitoring of donor-specific antibodies after transplantation; and 7) protocol biopsies. Between April 1, 2006, and March 31, 2009, 34 patients were transplanted according to this algorithm. Graft and patient survival rates did not differ from those in nonsensitized recipients. Antibody-mediated rejection episodes were <10% and infectious complications infrequent.