Modular-based psychotherapy (MoBa) versus cognitive-behavioural therapy (CBT) for patients with depression, comorbidities and a history of childhood maltreatment

• Verfasst von: Elsaeßer, Moritz [VerfasserIn]
• Verfasst von: Herpertz, Sabine [VerfasserIn]
• Verfasst von: Piosczyk, Hannah [VerfasserIn]
• Verfasst von: Jenkner, Carolin [VerfasserIn]
• Verfasst von: Hautzinger, Martin [VerfasserIn]
• Verfasst von: Schramm, Elisabeth [VerfasserIn]
• Titel: Modular-based psychotherapy (MoBa) versus cognitive-behavioural therapy (CBT) for patients with depression, comorbidities and a history of childhood maltreatment
• Titelzusatz: study protocol for a randomised controlled feasibility trial
• Verf.angabe: Moritz Elsaesser, Sabine Herpertz, Hannah Piosczyk, Carolin Jenkner, Martin Hautzinger, Elisabeth Schramm
• E-Jahr: 2022
• Jahr: 12 July 2022
• Umfang: 13 S.
• Fussnoten: Gesehen am 08.08.2022
• Titel Quelle: Enthalten in: BMJ open
• Ort Quelle: London : BMJ Publishing Group, 2011
• Jahr Quelle: 2022
• Band/Heft Quelle: 12(2022), 7, Artikel-ID e057672, Seite 1-13
• ISSN Quelle: 2044-6055
• DOI: doi:10.1136/bmjopen-2021-057672
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Adult psychiatry
• Sach-SW: Depression & mood disorders
• Sach-SW: PSYCHIATRY
• K10plus-PPN: 1816272698

Abstract

Introduction In depression treatment, most patients do not reach response or remission with current psychotherapeutic approaches. Major reasons for individual non-response are interindividual heterogeneity of etiological mechanisms and pathological forms, and a high rate of comorbid disorders. Personalised treatments targeting comorbidities as well as underlying transdiagnostic mechanisms and factors like early childhood maltreatment may lead to better outcomes. A modular-based psychotherapy (MoBa) approach provides a treatment model of independent and flexible therapy elements within a systematic treatment algorithm to combine and integrate existing evidence-based approaches. By optimally tailoring module selection and application to the specific needs of each patient, MoBa has great potential to improve the currently unsatisfying results of psychotherapy as a bridge between disorder-specific and personalised approaches. - Methods and analysis In a randomised controlled feasibility trial, N=70 outpatients with episodic or persistent major depression, comorbidity and childhood maltreatment are treated in 20 individual sessions with MoBa or standard cognitive-behavioural therapy for depression. The three modules of MoBa focus on deficits associated with early childhood maltreatment: the systems of negative valence, social processes and arousal. According to a specific questionnaire-based treatment algorithm, elements from cognitive behavioural analysis system of psychotherapy, mentalisation-based psychotherapy and/or mindfulness-based cognitive therapy are integrated for a personalised modular procedure.As a proof of concept, this trial will provide evidence for the feasibility and efficacy (post-treatment and 6-month follow-up) of a modular add-on approach for patients with depression, comorbidities and a history of childhood maltreatment. Crucial feasibility aspects include targeted psychopathological mechanisms, selection (treatment algorithm), sequence and application of modules, as well as training and supervision of the study therapists. - Ethics and dissemination This study obtained approval from the independent Ethics Committees of the University of Freiburg and the University of Heidelberg. All findings will be disseminated broadly via peer-reviewed articles in scientific journals and contributions to national and international conferences. - Trial registration number DRKS00022093.