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Verfasst von:Rahbari, Nuh Nabi [VerfasserIn]   i
 Schmidt, Thomas [VerfasserIn]   i
 Falk, Christine S. [VerfasserIn]   i
 Hinz, Ulf [VerfasserIn]   i
 Herber, Magdalene [VerfasserIn]   i
 Bork, Ulrich [VerfasserIn]   i
 Büchler, Markus W. [VerfasserIn]   i
 Weitz, Jürgen [VerfasserIn]   i
 Koch, Moritz [VerfasserIn]   i
Titel:Expression and prognostic value of circulating angiogenic cytokines in pancreatic cancer
Verf.angabe:Nuh N. Rahbari, Thomas Schmidt, Christine S. Falk, Ulf Hinz, Magdalene Herber, Ulrich Bork, Markus W. Büchler, Jürgen Weitz and Moritz Koch
E-Jahr:2011
Jahr:05 July 2011
Umfang:10 S.
Fussnoten:Gesehen am 08.09.2022
Titel Quelle:Enthalten in: BMC cancer
Ort Quelle:London : BioMed Central, 2001
Jahr Quelle:2011
Band/Heft Quelle:11(2011), Artikel-ID 286, Seite 1-10
ISSN Quelle:1471-2407
Abstract:Background: The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pancreatic cancer. Methods: Serum samples were collected preoperatively in patients undergoing surgery for localized pancreatic cancer (n = 74), metastatic pancreatic cancer (n = 24) or chronic pancreatitis (n = 20) and in healthy controls (n = 48). Quantitative enzyme-linked immunosorbent assays and multiplex protein arrays were used to determine circulating levels of VEGF, VEGFR-1, PlGF, PDGF-AA, PDGF-BB, Ang-1 and EGF. Multivariate analyses on cancer-specific survival were performed with a Cox proportional hazards model. Results: VEGF (p < 0.0001), PDGF-AA (p < 0.0001), Ang-1 (p = 0.002) and EGF (p < 0.0001) were differentially expressed in patients with pancreatic cancer compared to healthy controls. The presence of lymph node metastases was associated with increased levels of all CAC except for PlGF, whereas there were only minor associations of CAC with other clinicopathologic variables. The multivariate model including the entire angiogenic panel revealed high levels of circulating PDGF-AA (hazard ratio 4.58; 95% confidence interval 1.43 - 14.69) as predictor of poor cancer-specific survival, whereas high levels of PDGF-BB (0.15; 0.15 - 0.88), Ang-1 (0.30; 0.10 - 0.93) and VEGF (0.24; 0.09 - 0.57) were associated with a favorable prognosis. Conclusion: Circulating levels of certain angiogenic cytokines correlate with patients' prognosis after resection for pancreatic cancer, if a panel of several CAC is considered simultaneously. These data should be considered in future studies evaluating angiogenic factors as prognostic biomarkers and therapeutic targets in patients with pancreatic cancer.
DOI:doi:10.1186/1471-2407-11-286
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1186/1471-2407-11-286
 DOI: https://doi.org/10.1186/1471-2407-11-286
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Chronic Pancreatitis
 Metastatic Pancreatic Cancer
 Pancreatic Cancer
 Vascular Endothelial Growth Factor
 Vascular Endothelial Growth Factor Level
K10plus-PPN:1816290483
Verknüpfungen:→ Zeitschrift

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