Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Ramalingam, Suresh [VerfasserIn]   i
 Spigel, David R. [VerfasserIn]   i
 Chen, David [VerfasserIn]   i
 Steins, Martin [VerfasserIn]   i
 Engelman, Jeffrey A. [VerfasserIn]   i
 Schneider, Claus-Peter [VerfasserIn]   i
 Novello, Silvia [VerfasserIn]   i
 Eberhardt, Wilfried E. E. [VerfasserIn]   i
 Crino, Lucio [VerfasserIn]   i
 Habben, Kai [VerfasserIn]   i
 Liu, Lian [VerfasserIn]   i
 Jänne, Pasi A. [VerfasserIn]   i
 Brownstein, Carrie M. [VerfasserIn]   i
 Reck, Martin [VerfasserIn]   i
Titel:Randomized phase II study of Erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancer
Verf.angabe:Suresh S. Ramalingam, David R. Spigel, David Chen, Martin B. Steins, Jeffrey A. Engelman, Claus-Peter Schneider, Silvia Novello, Wilfried E. E. Eberhardt, Lucio Crino, Kai Habben, Lian Liu, Pasi A. Jänne, Carrie M. Brownstein, and Martin Reck
E-Jahr:2011
Jahr:October 24, 2011
Umfang:7 S.
Fussnoten:Gesehen am 09.09.2022
Titel Quelle:Enthalten in: Journal of clinical oncology
Ort Quelle:Alexandria, Va. : American Society of Clinical Oncology, 1983
Jahr Quelle:2011
Band/Heft Quelle:29(2011), 34, Seite 4574-4580
ISSN Quelle:1527-7755
Abstract:Purpose R1507 is a selective, fully human, recombinant monoclonal antibody (immunoglobulin G1 subclass) against insulin-like growth factor-1 receptor (IGF-1R). The strong preclinical evidence supporting coinhibition of IGF-1R and epidermal growth factor receptor (EGFR) as anticancer therapy prompted this study. Patients and Methods Patients with advanced-stage non-small-cell lung cancer (NSCLC) with progression following one or two prior regimens, Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2, and measurable disease were eligible. Patients were randomly assigned to receive erlotinib (150 mg orally once a day) in combination with either placebo, R1507 9 mg/kg weekly, or R1507 16 mg/kg intravenously once every 3 weeks. Treatment cycles were repeated every 3 weeks. The primary end point was comparison of the 12-week progression-free survival (PFS) rate. Results In all, 172 patients were enrolled: median age, 61 years; female, 33%; never-smokers, 12%; and performance status 0 or 1, 88%. The median number of R1507 doses was six for the weekly arm and 3.5 for the every-3-weeks arm. Grades 3 to 4 adverse events occurred in 37%, 44%, and 48% of patients with placebo, R1507 weekly, and R1507 every 3 weeks, respectively. The 12-week PFS rates were 39%, 37%, and 44%, and the median overall survival was 8.1, 8.1, and 12.1 months for the three groups, respectively, with statistically nonsignificant hazard ratios. The 12-week PFS rate in patients with KRAS mutation was 36% with R1507 compared with 0% with placebo. Conclusion The combination of R1507 with erlotinib did not provide PFS or survival advantage over erlotinib alone in an unselected group of patients with advanced NSCLC. Predictive biomarkers are essential for further development of combined inhibition of IGF-1R and EGFR.
DOI:doi:10.1200/JCO.2011.36.6799
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1200/JCO.2011.36.6799
 Volltext: https://ascopubs.org/doi/pdf/10.1200/JCO.2011.36.6799
 DOI: https://doi.org/10.1200/JCO.2011.36.6799
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:181634480X
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68962904   QR-Code
zum Seitenanfang