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| Verfasst von: | Nazario-Yepiz, Nestor O. [VerfasserIn]  |
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| | Sobaberas, Jaime Fernández [VerfasserIn] |
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| | Lyman, Roberta [VerfasserIn] |
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| | Iii, Marion R. Campbell [VerfasserIn] |
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| | Shankar, Vijay [VerfasserIn] |
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| | Anholt, Robert R. H. [VerfasserIn] |
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| | Mackay, Trudy F. C. [VerfasserIn] |
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| Titel: | Physiological and metabolomic consequences of reduced expression of the Drosophila brummer triglyceride Lipase |
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| Verf.angabe: | Nestor O. Nazario-Yepiz, Jaime Fernández Sobaberas, Roberta Lyman, Marion R. Campbell Iii, Vijay Shankar, Robert R.H. Anholt, Trudy F.C. Mackay |
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| E-Jahr: | 2021 |
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| Jahr: | September 21, 2021 |
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| Umfang: | 23 S. |
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| Fussnoten: | Gesehen am 09.09.2022 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 16(2021), 9, Artikel-ID e0255198, Seite 1-23 |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Disruption of lipolysis has widespread effects on intermediary metabolism and organismal phenotypes. Defects in lipolysis can be modeled in Drosophila melanogaster through genetic manipulations of brummer (bmm), which encodes a triglyceride lipase orthologous to mammalian Adipose Triglyceride Lipase. RNAi-mediated knock-down of bmm in all tissues or metabolic specific tissues results in reduced locomotor activity, altered sleep patterns and reduced lifespan. Metabolomic analysis on flies in which bmm is downregulated reveals a marked reduction in medium chain fatty acids, long chain saturated fatty acids and long chain monounsaturated and polyunsaturated fatty acids, and an increase in diacylglycerol levels. Elevated carbohydrate metabolites and tricarboxylic acid intermediates indicate that impairment of fatty acid mobilization as an energy source may result in upregulation of compensatory carbohydrate catabolism. bmm downregulation also results in elevated levels of serotonin and dopamine neurotransmitters, possibly accounting for the impairment of locomotor activity and sleep patterns. Physiological phenotypes and metabolomic changes upon reduction of bmm expression show extensive sexual dimorphism. Altered metabolic states in the Drosophila model are relevant for understanding human metabolic disorders, since pathways of intermediary metabolism are conserved across phyla. |
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| DOI: | doi:10.1371/journal.pone.0255198 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0255198 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255198 |
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| | DOI: https://doi.org/10.1371/journal.pone.0255198 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Carbohydrate metabolism |
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| | Drosophila melanogaster |
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| | Fats |
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| | Lipid metabolism |
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| | Metabolic pathways |
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| | Metabolites |
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| | Metabolomics |
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| | Sleep |
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| K10plus-PPN: | 1816345660 |
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| Verknüpfungen: | → Zeitschrift |
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Physiological and metabolomic consequences of reduced expression of the Drosophila brummer triglyceride Lipase / Nazario-Yepiz, Nestor O. [VerfasserIn]; September 21, 2021 (Online-Ressource)
